Prenatal Exposure to Cigarette Smoke and Benign Breast Disease
Prenatal Exposure to Cigarette Smoke and Benign Breast Disease
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DOI：
10.1097/ede.0b013e3181e9c118
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发表时间：
2010-09-01
期刊：
影响因子：
5.4
通讯作者：
Buka, Stephen L.
中科院分区：
文献类型：
--
作者：
Liu, Tianli;Gatsonis, Constantine A.;Buka, Stephen L.
背景：实验研究表明，香烟烟雾含有潜在的人体乳房毒素，且产前的毒性影响大于晚年的影响。方法：研究样本包括810名母亲在1959-1966年间在波士顿和普罗维登斯参加合作围产期项目的妇女。这些女性从怀孕到中年一直被跟踪观察。孕期吸烟的信息是在产前访问期间前瞻性收集的。我们确定了146名女性，她们被一名健康专业人士告知自己患有良性乳房疾病。采用对数二项回归模型和广义估计方程方法对母亲吸烟与子代良性乳腺疾病的关系进行量化。结果：母亲孕期吸烟与子代患良性乳腺疾病的风险呈正相关。特别是，与母亲在怀孕期间从不吸烟的妇女相比，母亲每天吸烟一包或更多的妇女患良性乳房疾病的可能性高1.7倍(相对风险=1.7[95%可信区间=1.2-2.5])。这种关联与女性的年龄、种族、教育程度、月经初潮年龄、产次、肥胖、出生体重和母亲孕期年龄无关。结论：产前大量吸烟与成年后患良性乳腺疾病的风险增加有关。
Background: Experimental studies have indicated that cigarette smoke contains potential human breast toxins and that the toxic influence during the prenatal period is greater than that of later life.Methods: The study sample includes 810 women whose mothers enrolled in the Collaborative Perinatal Project between 1959 and 1966 in Boston and Providence. These women have been followed from gestation until middle-age. Information on maternal smoking during pregnancy was prospectively collected during prenatal visits. We identified 146 women who had been told by a health professional that they had benign breast disease. Log-binomial regression models with Generalized Estimating Equation methods were employed to quantify the association between maternal smoking and benign breast disease among offspring.Results: There was a positive association between maternal smoking during pregnancy and the risk of benign breast disease among offspring. In particular, women whose mother smoked 1 pack or more per day were 1.7 times more likely to develop benign breast disease (relative risk = 1.7 [95% confidence interval = 1.2-2.5]) in comparison with women whose mother never smoked during pregnancy. The association was independent of women's age, race, education, age at menarche, parity, obesity, birth weight, and maternal age at pregnancy.Conclusions: Exposure to heavy cigarette smoking during the prenatal period was associated with an increased risk of benign breast disease in adulthood.