Yamaguchi M, Kotani K, Tsuzaki K, Motokubota N, Komai N, Sakane N, Moritani T, Nagai N. The CLOCK 3111T/C single nucleotide polymorphism and daytime fluctuations of gastric motility in healthy young women: a preliminary study.
Yamaguchi M, Kotani K, Tsuzaki K, Motokubota N, Komai N, Sakane N, Moritani T, Nagai N. The CLOCK 3111T/C single nucleotide polymorphism and daytime fluctuations of gastric motility in healthy young women: a preliminary study.
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Yamaguchi M、Kotani K、Tsuzaki K、Motokubota N、Komai N、Sakane N、Moritani T、Nagai N。健康年轻女性的 CLOCK 3111T/C 单核苷酸多态性和胃动力的日间波动：一项初步研究。
DOI：
10.1080/07420528.2017.1373660
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发表时间：
2017
影响因子：
2.8
通讯作者：
Nagai N
中科院分区：
文献类型：
--
作者：
Yamaguchi M;Kotani K;Tsuzaki K;Motokubota N;Komai N;Sakane N;Moritani T;Nagai N
据报道，昼夜运动输出周期（CLOCK）基因的3111T/C单核苷酸多态性（SNP）影响早餐前的胃运动。人们感兴趣的是，这种SNP是否会影响白天的运动。我们研究了34名定时用餐的年轻女性在8:00至20:00期间clock3111t /C SNP与胃运动参数之间的关系。主要（T/T）和次要（T/C）等位基因携带者在餐前和餐后的日间胃动力波动相似。clocksnp对日间胃运动的影响可能小于食物刺激。
The 3111T/C single nucleotide polymorphism (SNP) ofCircadian Locomotor Output Cycles Kaput(CLOCK) gene reportedly affects gastric motility before breakfast. It is of interest to know whether this SNP can affect the motility during the daytime. We investigated the association between theCLOCK3111T/C SNP and several gastric motility parameters during the time period from 8:00 to 20:00 in 34 young women with scheduled meals. There were similar daytime fluctuations in gastric motility before and after the meals between the major (T/T) and minor (T/C) allele carriers. TheCLOCKSNP may affect daytime gastric motility less than food stimulation.