Uncorrelated changes of subunit stability can generate length-dependent disassembly of treadmilling filaments
Uncorrelated changes of subunit stability can generate length-dependent disassembly of treadmilling filaments
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DOI：
10.1088/1478-3975/6/4/046016
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发表时间：
2009-12-01
期刊：
影响因子：
2
通讯作者：
Kruse, K.
中科院分区：
文献类型：
--
作者：
Erlenkaemper, C.;Kruse, K.
不受调控的聚合物组装通常会导致指数长度分布。然而，在活细胞中，细胞骨架丝的长度分布通常在有限值处显示出尖锐的最大值。我们讨论了一种简单的长度调节机制，该机制基于通过局部作用的细胞骨架蛋白产生有效的长度依赖性分解率。我们通过随机模拟分析稳态分布，并开发一种分析表征典型灯丝长度的方法。我们发现三种不同类型的行为：（1）无界细丝生长，（2）指数分布和（3）单峰分布，其可能非常尖锐，标准差远小于平均细丝长度。我们讨论了我们的结果对亚细胞过程的可能影响。
Unregulated polymer assembly typically leads to exponential length distributions. In living cells, though, the length distribution of cytoskeletal filaments often shows a sharp maximum at a finite value. We discuss a simple mechanism for length regulation that is based on generating an effectively length-dependent disassembly rate by locally acting cytoskeletal proteins. We analyze steady-state distributions by stochastic simulations and develop a method to analytically characterize the typical filament length. We find three different types of behavior: (1) unbounded filament growth, (2) exponential distributions and (3) unimodal distributions, which can be very sharp with a standard deviation much smaller than the mean filament length. We discuss possible implications of our results for subcellular processes.