Keeping the gate closed: functions of the polycomb repressive complex PRC2 in development
Keeping the gate closed: functions of the polycomb repressive complex PRC2 in development
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DOI：
10.1111/tpj.12828
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发表时间：
2015-07-01
期刊：
影响因子：
7.2
通讯作者：
Hennig, Lars
中科院分区：
文献类型：
--
作者：
Mozgova, Iva;Koehler, Claudia;Hennig, Lars
植物个体发育依赖于个体发育阶段之间正确的过渡时间和顺序。它们是由基因表达模式指定的，这些模式是由激活因子和抑制因子的平衡作用建立的。多梳抑制复合体(PRCs)是一种进化上保守的表观基因抑制系统，它控制着细胞、组织和器官特性的建立和维持，有助于发育程序的正确执行。PRC2是一个四亚基的组蛋白甲基转移酶复合体，它催化组蛋白H3(H3K27me3)上赖氨酸27的三甲基化，从而导致染色质结构的改变和持久的基因抑制。本文综述了植物中已知的不同的PRC2复合体的组成和分子功能，重点阐述了PRC2在调节不同发育阶段的建立和它们之间的转换中所起的作用。
Plant ontogeny relies on the correct timing and sequence of transitions between individual developmental phases. These are specified by gene expression patterns that are established by the balanced action of activators and repressors. Polycomb repressive complexes (PRCs) represent an evolutionarily conserved system of epigenetic gene repression that governs the establishment and maintenance of cell, tissue and organ identity, contributing to the correct execution of the developmental programs. PRC2 is a four-subunit histone methyltransferase complex that catalyzes trimethylation of lysine 27 on histone H3 (H3K27me3), which contributes to the change of chromatin structure and long-lasting gene repression. Here, we review the composition and molecular function of the different known PRC2 complexes in plants, and focus on the role of PRC2 in mediating the establishment of different developmental phases and transitions between them.