Metabolism and toxicity of styrene.
Metabolism and toxicity of styrene.
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DOI：
10.1289/ehp.7511115
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发表时间：
1975-06
影响因子：
10.4
通讯作者：
Leibman KC
中科院分区：
文献类型：
--
作者：
Leibman KC
简要综述了苯乙烯在人体和实验动物体内的吸收、血液水平、分布、排泄和生物转化。苯乙烯的急性毒性似乎与它的生物转化无关。慢性接触苯乙烯导致器官毒性的报告很少；然而，由于苯乙烯代谢的主要中间体是环氧化物，因此形成部位的共价结合可能导致肝毒性。
The absorption, blood levels, distribution, excretion, and biotransformation of styrene in man and experimental animals are briefly reviewed. The acute toxicity of styrene appears to be unrelated to its biotransformation. Reports of organ toxicity upon chronic exposure to styrene are rare; however, since the chief intermediate in styrene metabolism is an epoxide, hepatotoxicity due to covalent binding at the site of formation appears to be a possibility.