Increase in caudate nuclei volumes of first-episode schizophrenic patients taking antipsychotic drugs.
Increase in caudate nuclei volumes of first-episode schizophrenic patients taking antipsychotic drugs.
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DOI：
10.1176/ajp.151.10.1430
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发表时间：
1994-10
期刊：
影响因子：
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通讯作者：
M. Chakos;J. Lieberman;R. Bilder;M. Borenstein;G. Lerner;B. Bogerts;Houwei Wu;B. Kinon;M. Ashtari
中科院分区：
文献类型：
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作者：
M. Chakos;J. Lieberman;R. Bilder;M. Borenstein;G. Lerner;B. Bogerts;Houwei Wu;B. Kinon;M. Ashtari
目的研究有少量抗精神病药史的首发精神分裂症患者尾状核的病理形态。方法应用磁共振成像(MRI)对29例首发精神分裂症患者和10例健康对照组进行纵向尾状核病理形态检查。在受试者进入研究后和18个月的随访期内进行核磁共振扫描。在18个月的时间里，患者接受了标准化的抗精神病药物治疗。在T1加权冠状切片上对大脑皮层、侧脑室和尾状核进行体积评估。此外，在基线和治疗期间对患者进行了系统的精神病理学评估。结果在18个月的治疗间隔中，患者的尾状核体积增加了5.7%，而对照组在同一时间段减少了1.6%。患者在第一次扫描前接受抗精神病药物的量较多，在第一次扫描时年龄较小，与尾状核体积的较大增加相关。结论年轻首发精神分裂症患者在治疗过程中早期出现尾状核增大。这可能是抗精神病药物治疗和年轻患者多巴胺能神经系统可塑性之间相互作用的结果。
OBJECTIVE This study examined the pathomorphology of the caudate nuclei in first-episode schizophrenic patients with minimal previous neuroleptic exposure. METHOD Magnetic resonance imaging (MRI) of the brain was used to examine longitudinally the caudate pathomorphology in 29 first-episode schizophrenic patients and 10 healthy comparison subjects. MRI scans were obtained after the subjects entered the study and at 18-month follow-up. The patients were treated with standardized neuroleptic regimens during the 18-month period. Volumetric assessments of the cerebral cortex, lateral ventricles, and caudate nuclei were performed on T1-weighted coronal brain sections. In addition, the patients were systematically evaluated for psychopathology at baseline and during treatment. RESULTS Caudate volumes increased 5.7% in the patients during the 18-month treatment interval, whereas they decreased 1.6% in the comparison subjects over the same time period. Greater amounts of antipsychotic medication received by patients before the first scan and younger age at the time of the first scan were associated with larger increases in caudate volume. CONCLUSIONS Caudate enlargement occurs early in the course of treatment in young first-episode schizophrenic patients. This may be a result of an interaction between neuroleptic treatment and the plasticity of dopaminergic neuronal systems in young patients.