Quantitative trait loci analysis of human event-related brain potentials: P3 voltage
Quantitative trait loci analysis of human event-related brain potentials: P3 voltage
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DOI：
10.1016/s0168-5597(98)00002-1
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发表时间：
1998-04-01
期刊：
影响因子：
--
通讯作者：
Bloom, FE
中科院分区：
文献类型：
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作者：
Begleiter, H;Porjesz, B;Bloom, FE
P3事件相关脑电位（ERP）是刺激开始后300 - 500 ms之间发生的头皮记录的脑电图活动的正向电压变化。当刺激被感知，记忆操作被占用，注意力资源被分配到它的处理时，它就会被引出。由于这一ERP成分反映了基本的认知过程，因此在基础和临床研究中，它已被广泛用作人类心理功能的评估。特别是，P3属性是可遗传的，并已证明相当有希望作为一种手段，以确定个人的遗传风险酗酒。我们对来自受影响个体密度高的家庭的大样本进行了定量连锁分析。分析表明，人类基因组的几个区域包含与ERP的P3组分的产生相关的遗传位点，这是人类神经电活动的功能组织的潜在候选位点。(C)1998爱思唯尔科学爱尔兰有限公司
The P3 event-related brain potential (ERP) is a positive-going voltage change of scalp-recorded electroencephalographic activity that occurs between 300-500 ms after stimulus onset. It is elicited when a stimulus is perceived, memory operations an engaged, and attentional resources are allocated toward its processing. Because this ERP component reflects fundamental cognitive processing, it has found wide utility as an assessment of human mental function in basic and clinical studies. In particular, P3 attributes are heritable and have demonstrated considerable promise as a means to identify individuals at genetic risk for alcoholism. We have conducted a quantitative linkage analysis on a large sample from families with a high density of affected individuals. The analyses suggest that several regions of the human genome contain genetic loci related to the generation of the P3 component of the ERP, which are possible candidate loci underlying the functional organization of human neuroelectric activity. (C) 1998 Elsevier Science Ireland Ltd.