Longitudinal study of platelet size changes in gestation and predictive power of elevated MPV in development of pre-eclampsia
Longitudinal study of platelet size changes in gestation and predictive power of elevated MPV in development of pre-eclampsia
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DOI：
10.1002/pd.2126
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发表时间：
2008-11-01
影响因子：
3
通讯作者：
Mungen, Ercument
中科院分区：
文献类型：
--
作者：
Dundar, Ozgur;Yoruk, Pinar;Mungen, Ercument
目的本队列的目的是调查是否有任何血液学变化检测的简单的全血细胞计数（CBC）先兆子痫的发展和这些标志物在临床实践中的诊断价值为prediction of pre-eclampsia.Methods所有孕妇，在第一个三个月，参加加塔海达帕萨教学医院产科门诊常规产科护理登记。常规产科护理包括每月访视，直至第32周。在第32周和第36周之间每两个月进行一次访视。此后每周一次。根据这项研究，每次访问都从女性Lit中采集CBC并记录。结果1336例孕妇中有107例（8%）发生子痫前期。除平均血小板体积（MPV）值外，两组间CBC参数相似。从第24孕周到出生时，先兆子痫孕妇的MPV值显著高于正常对照组。在先兆子痫组中，诊断的平均孕龄为33.8周，并检测到显着的MPV增加约4.6周（范围2.8-5.9 wk.结论我们的研究提供了证据，MPV逐渐增加，受先兆子痫影响的孕妇与正常妊娠的妇女相比。版权所有（C）2008年约翰威利父子。公司
Objectives The aim of this cohort is to investigate whether any haematologic changes detectable by simple complete blood count (CBC) precede pre-eclampsia development and the diagnostic value of these markers in clinical practice for prediction of pre-eclampsia.Methods All pregnant women, in the first trimester, attending to GATA Haydarpasa Teaching Hospital Obstetric Outpatient Clinic for routine obstetric care were enrolled. Routine obstetric care consisted of monthly visits until 32nd week. bimonthly visits between 32nd and 36th week. and weekly thereafter. According to the study, protocol CBC was taken from women Lit each visit and recorded. After delivery, outcome data were obtained.Results A total of 1336 women were included into the statistical analysis and 107 (8%) of them developed pre-eclampsia. Parameters of CBC were similar between groups other than mean platelet Volume (MPV) values. MPV values of pre-eclamptic women were significantly higher than normotensive Counterparts from 24th gestational week up to gestational week at birth. In pre-eclamptic group, mean gestational age of diagnosis was 33.8 weeks and significant MPV increase was detected to precede the diagnosis by approximately 4.6 weeks (range 2.8-5.9 weeks).Conclusions Our Study provides evidence that MPV gradually increases in pregnant women affected by pre-eclampsia compared to women with normal pregnancies. Copyright (C) 2008 John Wiley & Sons. Ltd.