Perfluorooctane sulfonate alternatives and metabolic syndrome in adults: New evidence from the Isomers of C8 Health Project in China
Perfluorooctane sulfonate alternatives and metabolic syndrome in adults: New evidence from the Isomers of C8 Health Project in China
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全氟辛烷磺酸替代品与成人代谢综合征：中国 C8 异构体健康项目的新证据
DOI：
10.1016/j.envpol.2021.117078
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发表时间：
2021
影响因子：
8.9
通讯作者：
Dong Guang-Hui
中科院分区：
文献类型：
--
作者：
Yu Shu;Feng Wen-Ru;Liang Zi-Mian;Zeng Xiao-Yun;Bloom Michael S.;Hu Guo-Cheng;Zhou Yang;Ou Yan-Qiu;Chu Chu;Li Qing-Qing;Yu Yunjiang;Zeng Xiao-Wen;Dong Guang-Hui
氯化多氟烷基醚磺酸盐(Cl-PFESA)是一种广泛使用的聚氟烷基物质(PFAS)，是全氟辛烷磺酸盐(PFOS)的普遍替代品。尽管体内和体外都有代谢毒性的证据，但还没有研究探索人类群体中氯-PFESAs浓度与代谢综合征(METS)的关系。为了帮助解决这一数据差距，我们量化了32种全氟辛烷磺酸，包括2种全氟辛烷磺酸替代氯-全氟辛烷磺酸(6：2和8：2氯-全氟辛烷磺酸)，来自中国研究中参与C8健康项目横断面异构体的1228名成年人。在多元回归模型中，使用单个PFA作为连续或分类预测因子来估计MET及其各组分的优势比(OR)和95%可信区间(CI)。使用概率贝叶斯核机回归(BKMR-P)检验全氟辛烷磺酸和蛋氨酸的总体混合物之间的关联。较高的血清PFAS浓度与较高的METs发病几率相关，并显示出统计学上显著的剂量-反应趋势(P趋势为0.001)。例如，血清6：2Cl-PFESA每增加1n单位(ng/mL)，甲硫氨酸的患病率就越高(OR=1.52，95%CI：1.25，1.85)。血清6：2Cl-PFESA浓度最高四分位数的蛋氨酸水平也是最低水平的2.26倍(95%CI：1.59，3.23)，女性中的比例尤其高(OR=66.41，95%CI：3.65，11.24)。BKMR-P分析显示，测量的PFAS的总体混合物与患METS的几率之间存在正相关，但仅限于女性。虽然我们的结果表明，暴露于氯-全氟辛烷磺酸与蛋氨酸有关，但还需要更多的纵向研究，以更明确地解决这些全氟辛烷磺酸替代品的潜在健康问题。
Chlorinated polyfluoroalkyl ether sulfonates (Cl-PFESAs), are ubiquitous alternatives to perfluorooctane sulfonate (PFOS), a widely used poly- and perfluoroalkyl substance (PFAS). Despite invivoand invitroevidence of metabolic toxicity, no study has explored associations of Cl-PFESAs concentrations with metabolic syndrome (MetS) in a human population. To help address this data gap, we quantified 32 PFAS, including 2 PFOS alternative Cl-PFESAs (6:2 and 8:2 Cl-PFESAs) in serum from 1228 adults participating in the cross-sectional Isomers of C8 Health Project in China study. The odds ratios (ORs) and 95% confidence intervals (CIs) of MetS and its various components were estimated using individual PFAS as a continuous or categorical predictor in multivariate regression models. The association between the overall mixture of PFAS and MetS was examined using probit Bayesian Kernel Machine Regression (BKMR-P). Greater serum PFAS concentrations were associated with higher odds of MetS and demonstrated a statistically significant dose-response trend (Pfor trend < 0.001). For example, each ln-unit (ng/mL) increase in serum 6:2 Cl-PFESA was associated with a higher prevalence of MetS (OR = 1.52, 95% CI: 1.25, 1.85). MetS was also 2.26 (95% CI: 1.59, 3.23) times more common in the highest quartile of serum 6:2 Cl-PFESA concentration than the lowest, and particularly high among women (OR = 6.41, 95% CI: 3.65, 11.24). The BKMR-P analysis showed a positive association between the overall mixture of measured PFAS and the odds of MetS, but was only limited to women. While our results suggest that exposure to Cl-PFESAs was associated with MetS, additional longitudinal studies are needed to more definitively address the potential health concerns of these PFOS alternatives.