The dopamine D2 receptor gene and depressive and anxious symptoms in childhood: associations and evidence for gene-environment correlation and gene-environment interaction.
The dopamine D2 receptor gene and depressive and anxious symptoms in childhood: associations and evidence for gene-environment correlation and gene-environment interaction.
复制标题
DOI：
10.1097/ypg.0b013e32833adccb
复制
发表时间：
2010-12
影响因子：
0.9
通讯作者：
Singh SM
中科院分区：
文献类型：
--
作者：
Hayden EP;Klein DN;Dougherty LR;Olino TM;Laptook RS;Dyson MW;Bufferd SJ;Durbin CE;Sheikh HI;Singh SM
研究表明多巴胺D2受体基因（DRD 2）Taq1A多态性的A1等位基因与抑郁症和焦虑症的发生有关。此外，最近的论文表明，该基因的A1等位基因的儿童可能会受到较少的积极养育，并且该基因对儿童症状的影响可能会受到养育的调节。我们试图在一个非临床的幼儿样本中使用行为测量来复制和扩展这些发现。在473名学龄前儿童及其母亲的样本中，收集了结构化的临床访谈措施和母亲对儿童症状的报告，并进行了标准化的亲子互动观察。采用访谈和父母报告方法，检测到DRD2 A1等位基因与抑郁和焦虑症状之间的关联。正如在以前的报告中发现，DRD2 A1等位基因的儿童得到较少的支持性养育，并显示出较高水平的负面情绪在亲子互动。进行了调解和节制测试。我们发现DRD2 A1等位基因和早期出现的焦虑和抑郁症状之间的关联，在社区样本的学龄前儿童，和证据的基因环境相关性和温和的主要影响的儿童基因型对儿童症状的养育。
Research implicates the A1 allele of the dopamine D2 receptor gene (DRD2) Taq1A polymorphism in the development of depression and anxiety. Furthermore, recent papers suggest that children with A1 allele of this gene may receive less positive parenting, and that the effects of this gene on child symptoms may be moderated by parenting. We sought to replicate and extend these findings using behavioral measures in a nonclinical sample of young children. In a sample of 473 preschool-aged children and their mothers, structured clinical interview measures and maternal reports of child symptoms were collected, and standardized observations of parent–child interactions were conducted. An association was detected between the DRD2 A1 allele and symptoms of depression and anxiety indexed using interview and parent report methods. As found in previous reports, children with the DRD2 A1 allele received less supportive parenting and displayed higher levels of negative emotionality during parent–child interactions. Tests of mediation and moderation were conducted. We found associations between the DRD2 A1 allele and early-emerging anxious and depressive symptoms in a community sample of preschool-aged children, and evidence of a gene–environment correlation and moderation of the main effect of child genotype on child symptoms by parenting.