MRI T1ρ and T2 mapping for the assessment of articular cartilage changes in patients with medial knee osteoarthritis after hemicallotasis osteotomy
MRI T1ρ and T2 mapping for the assessment of articular cartilage changes in patients with medial knee osteoarthritis after hemicallotasis osteotomy
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DOI：
10.1302/2046-3758.57.bjr-2016-0057.r1
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发表时间：
2016-07-01
影响因子：
4.6
通讯作者：
Mizuta, H.
中科院分区：
文献类型：
--
作者：
Nishioka, H.;Nakamura, E.;Mizuta, H.
ObjectivesThe purpose of this study was to clarify the appearance of the reparative tissue on the joint surface and to analyze the properties of the reparative tissue after hemicallotasis osteotomy（HCO）using MRI T1 rho and T2 mapping. MethodsCoronalT1 rho and T2 mapping and three-dimensional gradient-echo images were obtained from 20 subjects with medial knee osteoarthritis.我们在膝关节的内侧股骨髁（MFC）和内侧胫骨平台（MTP）的全层软骨上设置感兴趣区域（ROI），并测量软骨厚度（mm）和T1 rho和T2弛豫时间（ms）。采用单因素方差分析对软骨厚度、T1 rho和T2弛豫时间的时间依赖性变化进行统计学分析，并采用Scheffe's检验进行事后多重比较。软骨厚度在术前和术后一年时间点之间显示出显著增加（MFC; p = 0.003，MTP; p < 0.001）。软骨样修复组织的T1 rho值随时间推移无差异，但T2值在术前和术后1年时间点之间显著降低（MFC; p = 0.004，MTP; p = 0.040）.结论本研究阐明了纤维软骨-HCO后内侧间室关节面出现类似修复组织，MRI T1 rho和T2标测证实了这一点。
ObjectivesThe purpose of this study was to clarify the appearance of the reparative tissue on the articular surface and to analyse the properties of the reparative tissue after hemicallotasis osteotomy (HCO) using MRI T1 rho and T2 mapping.MethodsCoronal T1 rho and T2 mapping and three-dimensional gradient-echo images were obtained from 20 subjects with medial knee osteoarthritis. We set the regions of interest (ROIs) on the full-thickness cartilage of the medial femoral condyle (MFC) and medial tibial plateau (MTP) of the knee and measured the cartilage thickness (mm) and T1 rho and T2 relaxation times (ms). Statistical analysis of time-dependent changes in the cartilage thickness and the T1 rho and T2 relaxation times was performed using one-way analysis of variance, and Scheffe's test was employed for post hoc multiple comparison.ResultsThe cartilage-like repair tissue appeared on the cartilage surface of the medial compartment post-operatively, and the cartilage thickness showed a significant increase between the pre-operative and one-year post-operative time points (MFC; p = 0.003, MTP; p < 0.001). The T1 rho values of the cartilage-like repair tissue showed no difference over time, however, the T2 values showed a significant decrease between the pre-operative and one-year postoperative time points (MFC; p = 0.004, MTP; p = 0.040).ConclusionThis study clarified that the fibrocartilage-like repair tissue appeared on the articular surface of the medial compartment after HCO as evidenced by MRI T1 rho and T2 mapping.