Biomonitoring of Perfluoroalkyl Acids in Human Urine and Estimates of Biological Half-Life
Biomonitoring of Perfluoroalkyl Acids in Human Urine and Estimates of Biological Half-Life
复制标题
人尿液中全氟烷基酸的生物监测和生物半衰期的估计
DOI：
10.1021/es401905e
复制
发表时间：
2013-09-17
影响因子：
11.4
通讯作者：
Martin, Jonathan W.
中科院分区：
文献类型：
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作者：
Zhang, Yifeng;Beesoon, Sanjay;Martin, Jonathan W.
全氟烷基酸(PFAA)是一种持久性和生物累积性化合物，与不良健康后果有关。在人类血液中，PFAA既以直链异构体的形式存在，也以支链异构体的形式存在，但对于大多数直链同系物和所有支链异构体来说，消除速率是未知的。采自中国地区成人血、尿液配对标本86例。他们通过一种灵敏的异构体特异性方法进行分析，这使得首次能够在人类尿液中检测到许多PFAA。除全氟十一酸(PFUnA)外，所有PFAA的尿中含量与血液中的含量呈正相关。与相同碳链长度的全氟烷基磺酸盐(PFSA)相比，全氟烷基羧酸盐(PFCA)的排泄效率更高。一般来说，较短的全氟辛烷磺酸的排泄效率高于较长的全氟辛烷磺酸，但对于全氟辛烷磺酸，全氟辛烷磺酸(全氟辛烷磺酸，C8化合物)的排泄效率高于全氟己烷磺酸(全氟己烷磺酸，C6化合物)。在全氟辛酸(PFOS)和全氟辛酸(PFOA)异构体中，主要支链异构体的排泄效率高于相应的线形异构体。用一室模型估算了PFAAs的生物消除半衰期。在所有PFAA中，估计的算术平均消除半衰期从0.5+/-0.1年(对于一个分支的全氟辛烷磺酸异构体，5M-PF0A)到90+/-11年(对于一个分支的全氟辛烷磺酸异构体，1M-全氟辛烷磺酸)。尿排泄是短PFCA(C)的主要排泄途径
Perfluoroalkyl acids (PFAAs) are persistent and bioaccumulative compounds that have been associated with adverse health outcomes. In human blood, PFAAs exist as both linear and branched isomers, yet for most linear homologues, and for all branched isomers, elimination rates are unknown. Paired blood and urine samples (n = 86) were collected from adults in China. They were analyzed by a sensitive isomer-specific method that permitted the detection of many PFAAs in human urine for the first time. For all PFAAs except perfluoroundecanoate (PFUnA), levels in urine correlated positively with levels in blood. Perfluoroalkyl carboxylates (PFCAs) were excreted more efficiently than perfluoroalkane sulfonates (PFSAs) of the same carbon chain-length. In general, shorter PFCAs were excreted more efficiently than longer ones, but for PFSAs, perfluorooctanesulfonate (PFOS, a C8 compound) was excreted more efficiently than perfluorohexanesulfonate (PFHxS, a C6 compound). Among PFOS and perfluorooctanoate (PFOA) isomers, major branched isomers were more efficiently excreted than the corresponding linear isomer. A one-compartment model was used to estimate the biological elimination half lives of PFAAs. Among all PFAAs, the estimated arithmetic mean elimination half-lives ranged from 0.5 +/- 0.1 years (for one branched PFOA isomer, 5m-PF0A) to 90 +/- 11 years (for one branched PFOS isomer, 1m-PFOS). Urinary excretion was the major elimination route for short PFCAs (C