Epigenetics in carcinogenesis and cancer prevention
Epigenetics in carcinogenesis and cancer prevention
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DOI：
10.1111/j.1749-6632.2003.tb05976.x
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发表时间：
2003-01-01
期刊：
影响因子：
--
通讯作者：
Jones, PA
中科院分区：
文献类型：
--
作者：
Jones, PA
癌变是遗传和表观遗传异常逐步积累的过程，可导致细胞功能障碍。很明显，表观遗传变化对这一多步骤过程产生结果同样重要。这篇文章描述了表观遗传调节在癌变过程中可能发挥的不同作用，以及考虑到等式两边的早期检测和化学预防干预策略是如何有利的。
Carcinogenesis is a stepwise process of accumulation of genetic and epigenetic abnormalities that can lead to cellular dysfunction. It has become clear that epigenetic changes are equally important for this multistep process to produce its results. This article describes the different roles that epigenetic modulation may play during carcinogenesis and how an early detection and chemopreventive intervention strategy that takes both sides of the equation into account would be advantageous.