DEM simulation of the mixing behavior in a spheronization process
DEM simulation of the mixing behavior in a spheronization process
复制标题
滚圆过程中混合行为的 DEM 模拟
DOI：
10.1016/j.ces.2018.07.057
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发表时间：
2018
影响因子：
4.7
通讯作者：
Sergiy
中科院分区：
文献类型：
--
作者：
Dominik;Thommes;Markus;Antonyuk;Sergiy
用于制药的球形颗粒广泛采用挤压-滚圆工艺生产。为了在球化过程中获得均匀的球形颗粒形状，所有颗粒都暴露在相似的应力条件下是至关重要的。然而，在球化器中，靠近摩擦板的球团受到比环面顶部的球团高得多的应力，导致颗粒床内的应力分布极不均匀。因此，产品质量特别取决于球化器中的混合过程。在本研究中，使用DEM模拟分析了球化过程中的混合行为。对实验室球形器的实际几何形状和实际工艺参数进行了研究。为了确定接触模型湿球团的力学性能，采用挤压滚圆法制备的mcc基球团进行了各种单颗粒实验。空间混合具有不同的特征。除了根据统计分析确定混合程度外，还利用了Fokker-Planck方程。通过这种方法，得到了混合度随时间的空间分布。利用Fokker-Planck方程输运系数和色散系数的极向分布，阐明了球化器不同区域混合程度的变化过程。
Spherical pellets for pharmaceutical applications are widely produced by an extrusion-spheronization process. To achieve an equal, spherical pellet shape with a spheronization process, it is crucial that all pellets are exposed to similar stress conditions. However, in a spheronizer the pellets close to the friction plate are subjected to much higher stresses than pellets at the top of the torus, resulting in a strongly inhomogeneous stress distribution within the particle bed. Therefore, the product quality depends in particular on the mixing process in the spheronizer. In this study, the mixing behavior in a spheronization process is analyzed using DEM simulations. The real geometry and realistic process parameters of a lab scale spheronizer were investigated. To determine the mechanical properties of the wet pellets for the contact model, various single particle experiments were conducted with MCC-based pellets produced by extrusion-spheronization. The spatial mixing was characterized in different ways. Besides the determination of the degree of mixing based on statistical analysis, the Fokker-Planck equation was utilized. In this way the spatial distribution of the degree of mixing over the time was obtained. By using the poloidal distribution of the transport and dispersion coefficients of the Fokker-Planck equation the course of the degree of mixing in the different zones of the spheronizer was clarified.
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DOI：
--
发表时间：
1977
期刊：
影响因子：
--
作者：
K. Sommer
通讯作者：
K. Sommer
影响因子：
3.8
作者：
Fasano, A
通讯作者：
Fasano, A
DOI：
10.1016/j.compchemeng.2012.09.023
发表时间：
2013
期刊：
Comput. Chem. Eng.
影响因子：
--
作者：
J. Bouffard;F. Bertrand;J. Chaouki;H. Dumont
通讯作者：
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影响因子：
5.2
作者：
Aca Jovanović;Milada L. Pezo;L. Pezo;L. Lević
通讯作者：
Aca Jovanović;Milada L. Pezo;L. Pezo;L. Lević
影响因子：
3.5
作者：
Crueger, B.;Salikov, V.;Kuipers, J. A. M.
通讯作者：
Kuipers, J. A. M.