Masculinization of female fetus due to use of orally given progestins.
Masculinization of female fetus due to use of orally given progestins.
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由于使用口服孕激素而导致女性胎儿男性化。
DOI：
10.1001/jama.1960.03020100036007
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发表时间：
1960
影响因子：
--
通讯作者：
L. Wilkins
中科院分区：
文献类型：
--
作者：
L. Wilkins
一个明显男性化的女婴很容易被误认为是一个尿道下裂的男性或一个正常的男性单纯隐睾症。这种先天性疾病有时是由男性化肾上腺皮质增生引起的，但这里提供的数据表明，它也经常是由于母亲在治疗习惯性流产或先兆流产时使用孕激素引起的。本文分析了70例与母亲口服孕激素有关的女婴胎儿男性化的病例。其中31例使用17-α-乙炔基睾酮，35例使用17-α-乙炔基-19-去甲睾酮。在25例病例中，母亲服用了雌激素和孕激素，以便雌激素可以抵消孕激素的男性化作用，但证据表明雌激素并不能阻止胎儿男性化。这些数据并不反对使用孕酮，因为在所有情况下，所涉及的孕酮都是合成的。
A markedly masculinized female infant is readily mistaken for a hypospadic male or for a normal male with simple cryptorchism. This congenital condition is sometimes caused by virilizing adrenal hyperplasia, but data here presented show that it has also frequently resulted from administration of progestins to mothers in treating habitual or threatened abortion. Seventy cases of fetal masculinization of female infants associated with the oral administration of progestins to their mothers are analyzed. Thirty-one followed the use of 17-α-ethinyltestosterone, and 35 followed the use of 17-α-ethinyl-19--nortestosterone. In 25 cases the mothers were given estrogens with the progestins in order that the estrogen might offset the virilizing effect of the progestin, but the evidence showed that the estrogens did not prevent fetal masculinization. These data do not argue against the use of progesterone, for the progestins concerned in all cases were synthetic.