Association between LMP2/LMP7 genetic variability and cancer susceptibility, especially among Asians: evidence from a meta-analysis.
Association between LMP2/LMP7 genetic variability and cancer susceptibility, especially among Asians: evidence from a meta-analysis.
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LMP2/LMP7 遗传变异性与癌症易感性之间的关联，尤其是亚洲人：来自荟萃分析的证据
DOI：
10.18632/oncotarget.18752
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发表时间：
2017-09-22
期刊：
影响因子：
--
通讯作者：
Miao Y
中科院分区：
文献类型：
--
作者：
Wu Y;Liu DF;Zhang JJ;Li X;Lu ZP;Shi GD;Yuan H;Ge YG;Wu PF;Wang Y;Jiang KR;Miao Y
低分子质量蛋白(LMP)基因通过主要组织相容性复合体-I(MHC-I)复合体CD8+细胞毒性T淋巴细胞(CTL)途径在外源抗原处理机制中发挥重要作用。最近的研究报道了LMP2-60G>；A(Rs17587)和LMP7-145C>；A(Rs2071543)基因多态性与不同类型癌症的关系，但结果仍然不一致。为了得到可靠的结论，我们总结了现有的数据，并进行了荟萃分析，共涉及19项已发表的研究。证据来自PubMed、Google Scholar、Web of Science和中国国家知识基础设施(CNKI)数据库。结果表明，rs17587和rs2071543基因多态与隐性和纯合子模型中的癌症风险增加相关。按种族分层的分析表明，只有在亚洲人口中存在显著的相关性。此外，rs17587显示出对妇科癌症的易感性，而rs2071543则增加了患胃肠道和妇科癌症的风险。我们的结果表明，LMP2 rs17587和LMP7 rs2071543基因多态性可能是癌症的危险因素，特别是在亚洲人群中。还应该进行更大规模的多中心研究来验证我们的结果。
Low molecular mass protein (LMP) gene performs a critical role in the foreign antigen processing machine via the major histocompatibility complex-I (MHC-I) complex CD8+ cytotoxic T lymphocytes (CTL) pathway. Recent studies have reported the association of LMP2-60 G>A (rs17587) and LMP7-145 C>A (rs2071543) polymorphisms with various types of cancers, but the outcomes remained inconsistent. To obtain a reliable conclusion, we summarized available data and conducted a meta-analysis involving a total of 19 published studies. Evidences were obtained from the PubMed, Google Scholar, Web of Science and Chinese National Knowledge Infrastructure (CNKI) databases. The results demonstrated that the rs17587 and rs2071543 polymorphisms were associated with an increased cancer risk in the recessive and homozygote models. Stratified analyses by ethnicity indicated a significant association only in Asian population. Furthermore, rs17587 showed a greater susceptibility to gynecological cancers, while rs2071543 increased the risk of gastrointestinal and gynecological cancers. Our results indicate that the LMP2 rs17587 and LMP7 rs2071543 polymorphisms may act as risk factors for cancer, especially for Asian populations. Additional larger-scale multicenter studies should be performed to validate our results.