Perspective: The Dietary Inflammatory Index (DII)-Lessons Learned, Improvements Made, and Future Directions
Perspective: The Dietary Inflammatory Index (DII)-Lessons Learned, Improvements Made, and Future Directions
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DOI：
10.1093/advances/nmy071
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发表时间：
2019-03-01
影响因子：
9.3
通讯作者：
Hurley, Thomas G.
中科院分区：
文献类型：
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作者：
Hebert, James R.;Shivappa, Nitin;Hurley, Thomas G.
在过去的几十年里，关于炎症在健康中的作用的文献呈指数级增长。与此同时，饮食在调节炎症中的作用也得到了同样强烈的关注，文献的规模大约每4年翻一番。饮食炎症指数（DII）的开发提供了一种定量手段，用于评估饮食与健康结果（从炎症细胞因子的血液浓度到慢性疾病）相关的作用。基于从细胞培养到人类观察和实验研究的各种不同研究设计的文献，DII被设计为普遍适用于所有具有适当饮食评估的人类研究。在过去的4年中，DII已被用于近200项研究，并构成了12项荟萃分析的基础。在进行这项工作的过程中，在与总能量和营养摄入以及能量和营养密度有关的方法问题方面吸取了经验教训。因此，对原始算法进行了改进。在本文中，我们讨论了这些改进和我们对DII的误用和误解所做的观察，并为未来的发展提供了建议。
The literature on the role of inflammation in health has grown exponentially over the past several decades. Paralleling this growth has been an equally intense focus on the role of diet in modulating inflammation, with a doubling in the size of the literature approximately every 4 y. The Dietary Inflammatory Index (DII) was developed to provide a quantitative means for assessing the role of diet in relation to health outcomes ranging from blood concentrations of inflammatory cytokines to chronic diseases. Based on literature from a variety of different study designs ranging from cell culture to observational and experimental studies in humans, the DII was designed to be universally applicable across all human studies with adequate dietary assessment. Over the past 4 y, the DII has been used in > 200 studies and forms the basis for 12 meta-analyses. In the process of conducting this work, lessons were learned with regard to methodologic issues related to total energy and nutrient intake and energy and nutrient densities. Accordingly, refinements to the original algorithm have been made. In this article we discuss these improvements and observations that we made with regard to misuse and misinterpretation of the DII and provide suggestions for future developments.