Development of calcium phosphate cement for the augmentation of traumatically fractured porcine specimens using vertebroplasty.
Development of calcium phosphate cement for the augmentation of traumatically fractured porcine specimens using vertebroplasty.
复制标题
开发用于使用椎体成形术增强创伤性骨折猪标本的磷酸钙水泥。
DOI：
10.1016/j.jbiomech.2012.11.036
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发表时间：
2013
影响因子：
2.4
通讯作者：
Tarsuslugil SM
中科院分区：
文献类型：
--
作者：
Tarsuslugil SM
本研究的目的是开发和应用一种实验技术，以确定聚甲基丙烯酸甲酯（PMMA）和磷酸钙（CaP）骨水泥对创伤性骨折后加固椎体刚度和强度的生物力学影响。在猪三椎体节段中产生了12个爆裂型骨折。将样本随机分为两组（n=6），使用microCT成像并在轴向载荷下进行测试。两组骨折样本接受了椎体成形术，一组使用贝尔法斯特女王大学设计和开发的CaP骨水泥进行了加固。另一组用PMMA骨水泥（WHW Plastics，船体，英国）加固。对样本进行成像并重新测试。还对完整的单椎骨样本组（n=12）进行了成像，并在轴向载荷下进行了测试。发现断裂组和完整组的刚度显著降低（p<0.01），表明产生的断裂足够严重，对机械性能产生不利影响。显著增加PMMA骨水泥加固组的破坏载荷与加固前组相比有显著性差异（p<0.01），而加固前组无显著性差异（p> 0.05）在用CaP骨水泥增强的样本的破坏载荷中发现（p<0.01），这归因于显著的（p<0.05）与PMMA骨水泥相比，成功注入骨折的CaP骨水泥体积较低。可以通过使用本研究中开发的方法进一步研究骨水泥裂缝填充百分比、骨水泥模量对样本刚度和极限失效载荷的影响，以测试更具可注射性的CaP骨水泥。
The study aim was to develop and apply an experimental technique to determine the biomechanical effect of polymethylmethacrylate (PMMA) and calcium phosphate (CaP) cement on the stiffness and strength of augmented vertebrae following traumatic fracture. Twelve burst type fractures were generated in porcine three-vertebra segments. The specimens were randomly split into two groups (n=6), imaged using microCT and tested under axial loading. The two groups of fractured specimens underwent a vertebroplasty procedure, one group was augmented with CaP cement designed and developed at Queen's University Belfast. The other group was augmented with PMMA cement (WHW Plastics, Hull, UK). The specimens were imaged and re-tested . An intact single vertebra specimen group (n=12) was also imaged and tested under axial loading. A significant decrease (p<0.01) was found between the stiffness of the fractured and intact groups, demonstrating that the fractures generated were sufficiently severe, to adversely affect mechanical behaviour. Significant increase (p<0.01) in failure load was found for the specimen group augmented with the PMMA cement compared to the pre-augmentation group, conversely, no significant increase (p<0.01) was found in the failure load of the specimens augmented with CaP cement, this is attributed to the significantly (p<0.05) lower volume of CaP cement that was successfully injected into the fracture, compared to the PMMA cement. The effect of the percentage of cement fracture fill, cement modulus on the specimen stiffness and ultimate failure load could be investigated further by using the methods developed within this study to test a more injectable CaP cement.