Survival of cancer cells is maintained by EGFR independent of its kinase activity
Survival of cancer cells is maintained by EGFR independent of its kinase activity
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DOI：
10.1016/j.ccr.2008.03.015
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发表时间：
2008-05-01
期刊：
影响因子：
50.3
通讯作者：
Hung, Mien-Chie
中科院分区：
文献类型：
--
作者：
Weihua, Zhang;Tsan, Rachel;Hung, Mien-Chie
表皮生长因子受体（EGFR）是一种与细胞增殖和存活相关的酪氨酸激酶受体，在许多上皮源性肿瘤中表达过度活跃。阻断EGFR激酶活性已被用于癌症治疗；然而，就其本身而言，似乎并没有达到最大的治疗效果。我们在这里报道，在人类癌细胞中，激酶非依赖性EGFR的功能是通过钠/葡萄糖共转运体1 （SGLT1）的相互作用和稳定来维持细胞内葡萄糖水平，从而防止自噬细胞死亡。
Expression of the epidermal growth factor receptor (EGFR), a receptor tyrosine kinase associated with cell proliferation and survival, is overactive in many tumors of epithelial origin. Blockade of the kinase activity of EGFR has been used for cancer therapy; however, by itself, it does not seem to reach maximum therapeutic efficacy. We report here that in human cancer cells, the function of kinase-independent EGFR is to prevent autophagic cell death by maintaining intracellular glucose level through interaction and stabilization of the sodium/glucose cotransporter 1 (SGLT1).