PENTATHIEPINS AND TRITHIANES FROM 2 LISSOCLINUM SPECIES AND A EUDISTOMA SP - INHIBITORS OF PROTEIN-KINASE-C
PENTATHIEPINS AND TRITHIANES FROM 2 LISSOCLINUM SPECIES AND A EUDISTOMA SP - INHIBITORS OF PROTEIN-KINASE-C
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DOI：
10.1016/s0040-4020(01)81200-x
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发表时间：
1994-11-07
期刊：
影响因子：
2.1
通讯作者：
MATTERN, MR
中科院分区：
文献类型：
--
作者：
COMPAGNONE, RS;FAULKNER, DJ;MATTERN, MR
来自帕劳的海鞘Lissoclinum japonicum含有抗微生物和抗真菌代谢物N，N-二甲基-5-（甲硫基）varacin（6）和3，4-二甲氧基-6-（2 '-N，N-二甲基氨基乙基）-5-（甲硫基）苯并三噻烷（7），这两种代谢物均以三氟乙酸盐的形式分离。从来自波恩佩的不同的Lissoclinum物种中分离出5-（甲硫基）varacin（8）和相应的三噻烷9的不可分离的2：3混合物，从来自波恩佩的Eudistoma物种中分离出3，4-去甲基varacin（10），作为三氟乙酸盐。五硫杂环庚三烯和三噻烷选择性抑制蛋白激酶C。
The ascidian Lissoclinum japonicum from Palau contained the antimicrobial and antifungal metabolites N,N-dimethyl-5-(methylthio)varacin (6) and 3,4-dimethoxy-6-(2'-N,N-dimethylaminoethyl)-5-(methylthio)benzotrithiane (7), both of which were isolated as the trifluoroacetate salts. An inseparable 2:3 mixture of 5-(methylthio)varacin (8) and the corresponding trithiane 9 was isolated from a different Lissoclinum species from Pohnpei and 3,4-desmethylvaracin (10), isolated as the trifluoroacetate salt, was obtained from a species of Eudistoma from Pohnpei. The pentathiepins and trithianes selectively inhibit protein kinase C.