The Efficacy of MAG-DHA for Correcting AA/DHA Imbalance of Cystic Fibrosis Patients
The Efficacy of MAG-DHA for Correcting AA/DHA Imbalance of Cystic Fibrosis Patients
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DOI：
10.3390/md16060184
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发表时间：
2018-06-01
期刊：
影响因子：
5.4
通讯作者：
Fortin, Samuel
中科院分区：
文献类型：
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作者：
Morin, Caroline;Cantin, Andre M.;Fortin, Samuel
补充omega-3多不饱和脂肪酸(n-3 PUFA)被认为可以改善必需脂肪酸缺乏症(EFAD)并减少囊性纤维化(CF)的炎症，但其临床研究的有效性仍不清楚。本研究的目的是确定含有二十二碳六烯酸单甘酯(MAG-DHA)的医疗食品如何影响红细胞脂肪酸组成和炎性循环介质的表达水平。我们进行了一项随机、双盲、先导性试验，包括15名18-48岁的囊性纤维化门诊患者。将患者分成2组，分别给予MAG-DHA或安慰剂(葵花油)治疗60天。患者每天睡前服用8x625 mg MAG-DHA软凝胶或8x625 mg安慰剂软凝胶，持续60天。血脂分析显示，每日补充1个月后，MAG-DHA可提高CF患者红细胞中二十二碳六烯酸(DHA)水平，降低花生四烯酸(AA)比值(AA/DHA)。数据还显示，添加MAG-DHA的CF患者血浆人白细胞弹性蛋白酶(PHLE)复合体和血液样本中IL-6的表达水平降低。提示MAG-DHA可纠正红细胞AA/DHA失衡，并可能通过降低CF患者血液中的PHLE复合体和IL-6发挥抗炎作用。
Omega-3 polyunsaturated fatty acid (n-3 PUFA) supplementations are thought to improve essential fatty acid deficiency (EFAD) as well as reduce inflammation in Cystic Fibrosis (CF), but their effectiveness in clinical studies remains unknown. The aim of the study was to determine how the medical food containing docosahexaenoic acid monoglyceride (MAG-DHA) influenced erythrocyte fatty acid profiles and the expression levels of inflammatory circulating mediators. We conducted a randomized, double blind, pilot trial including fifteen outpatients with Cystic Fibrosis, ages 18-48. The patients were divided into 2 groups and received MAG-DHA or a placebo (sunflower oil) for 60 days. Patients took 8 x 625 mg MAG-DHA softgels or 8 x 625 mg placebo softgels every day at bedtime for 60 days. Lipid analyses revealed that MAG-DHA increased docosahexaenoic acid (DHA) levels and decrease arachidonic acid (AA) ratio (AA/DHA) in erythrocytes of CF patients following 1 month of daily supplementation. Data also revealed a reduction in plasma human leukocyte elastase (pHLE) complexes and interleukin-6 (IL-6) expression levels in blood samples of MAG-DHA supplemented CF patients. This pilot study indicates that MAG-DHA supplementation corrects erythrocyte AA/DHA imbalance and may exert anti-inflammatory properties through the reduction of pHLE complexes and IL6 in blood samples of CF patients.