Over-expressedMST1impaired spatial memory via disturbing neural oscillation patterns in mice
Over-expressedMST1impaired spatial memory via disturbing neural oscillation patterns in mice
复制标题
过度表达的 MST1 通过干扰小鼠的神经振荡模式损害空间记忆
DOI：
10.1111/gbb.12678
复制
发表时间：
2020-06-29
影响因子：
2.5
通讯作者：
Zhang, Tao
中科院分区：
文献类型：
--
作者：
Shang, Yingchun;Yan, Yuxing;Zhang, Tao
The activated mammalian Ste20-like serine/threonine kinases 1 (MST1) was found in the central nervous system diseases, such as cerebral ischemia, stroke and ALS, which were related with cognitions. The aim of this study was to examine the effect of elevated MST1 on memory functions in C57BL/6J mice. We also explored the underlying mechanism about the pattern alteration of neural oscillations, closely associated with cognitive dysfunctions, at different physiological rhythms, which were related to a wide range of basic and higher-level cognitive activities. A mouse model of the adeno-associated virus (AAV)-mediated overexpression of MST1 was established. The behavioral experiments showed that spatial memory was significantly damaged in MST1 mice. The distribution of either theta or gamma power was clearly disturbed in MST1 animals. Moreover, the synchronization in both theta and gamma rhythms, and theta-gamma cross-frequency coupling were significantly weakened in MST1 mice. In addition, the expressions of GABAA receptor, GAD67 and parvalbumin (PV) were obviously increased in MST1 mice. Meanwhile, blocking MST1 activity could inhibit the activation of FOXO3a and YAP. The above data suggest that MST1-overexpression may induce memory impairments via disturbing the patterns of neural activities, which is possibly associated with the abnormal GABAergic expression level.
