Measuring glutamate receptor activation-induced apoptotic cell death in ischemic rat retina using the TUNEL assay.
Measuring glutamate receptor activation-induced apoptotic cell death in ischemic rat retina using the TUNEL assay.
复制标题
使用TUNEL分析测量缺血性大鼠视网膜中谷氨酸受体激活诱导的凋亡细胞死亡。
DOI：
10.1007/978-1-61779-108-6_16
复制
发表时间：
2011
期刊：
影响因子：
--
通讯作者：
Kim KY
中科院分区：
文献类型：
--
作者：
Ju WK;Kim KY
Glutamate receptor activation-mediated excitotoxicity has been hypothesized to cause cell death in both acute and chronic neurodegenerative diseases including glaucoma. Although the precise mechanisms of ischemia-induced neuronal death are unknown, glutamate excitotoxicty-induced apoptotic cell death is considered to be an important component of postischemic damage in the retina. The blockade of apoptotic cell death induced by glutamate receptor activation provides strong evidence that glutamate excitotoxicity-induced apoptotic cell death may be a central mechanism of cell death in ischemic rat retina. We have shown that there is TUNEL-positive apoptotic cell death in the outer nuclear layer, inner nuclear layer and ganglion cell layer of the ischemic rat retina at 12 h.
