EFFECTS OF ANTIDEPRESSANT AGENTS ON SYNTHESIS OF BRAIN MONO-AMINES
EFFECTS OF ANTIDEPRESSANT AGENTS ON SYNTHESIS OF BRAIN MONO-AMINES
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DOI：
10.1007/bf01579067
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发表时间：
1978-01-01
影响因子：
3.3
通讯作者：
LINDQVIST, M
中科院分区：
文献类型：
--
作者：
CARLSSON, A;LINDQVIST, M
本文通过测定芳香族L-氨基酸脱羧酶抑制剂(3-羟基苯肼，100 mg/kg ip)诱导大鼠脑内5-羟色氨酸、去甲肾上腺素和多巴胺合成的方法，研究了17种已知或可能的抗抑郁药物对大鼠脑内5-羟色胺、去甲肾上腺素和多巴胺合成的影响。所有已确定的5-羟色胺、去甲肾上腺素和多巴胺摄取抑制剂都抑制了各自单胺的合成，可能是通过影响受体介导的反馈机制。在阻断递质摄取和抑制递质合成之间似乎存在密切的相关性。这一结果支持了目前关于抗抑郁药作用模式的观点。
The effect of 17 established or possible antidepressant agents on the synthesis of 5-HT [serotonin], noradrenaline [norepinephrine] and dopamine in rat brain was investigated by measuring the accumulation of 5-hydroxytryptophan and DOPA induced by an inhibitor of the aromatic L-aminoacid decarboxylase (3-hydroxybenzylhydrazine hydrochloride, 100 mg/kg i.p.). All the established inhibitors of 5-HT, noradrenaline and dopamine uptake inhibited the synthesis of the respective monoamines, presumably by influencing a receptor-mediated feedback mechanism. A close correlation appears to exist between blockade of transmitter uptake and inhibition of transmitter synthesis. The results support current ideas on the mode of action of antidepressant agents.