OPIOID AND NONOPIOID INTERACTIONS IN 2 FORMS OF STRESS-INDUCED ANALGESIA
OPIOID AND NONOPIOID INTERACTIONS IN 2 FORMS OF STRESS-INDUCED ANALGESIA
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DOI：
10.1016/0091-3057(93)90100-8
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发表时间：
1993-05-01
影响因子：
3.6
通讯作者：
MAIER, SF
中科院分区：
文献类型：
--
作者：
GRISEL, JE;FLESHNER, M;MAIER, SF
应激性环境事件激活疼痛抑制的内源性机制。在某些情况下，镇痛作用被纳洛酮/纳洛酮（“阿片类”）阻断，而在其他情况下则不是（“非阿片类”）。这两类镇痛的存在导致了它们如何相关的问题。在Kirshgessner、Bodnar和Pasternak（1982年）提出的侧支抑制模型中，阿片类和非阿片类机制被视为以相互抑制的方式起作用。在本实验中，大鼠暴露于两种环境应激源中的任一种，所述环境应激源在注射阿片拮抗剂纳洛酮或激动剂吗啡后产生非阿片类应激诱导的镇痛（SIA）。在纳洛酮的存在下，无论是冷水游泳（CWS）或社会失败产生的SIA增强。这些相同的SIAs被发现减弱吗啡的镇痛作用，表明阿片系统的激活可以抑制非阿片类药物的抑制作用。这些结果支持了阿片类和非阿片类机制在某些形式的应激镇痛中的抑制性相互作用。
Stressful environmental events activate endogenous mechanisms of pain inhibition. Under some circumstances the analgesia is blocked by naloxone/naltrexone (''opioid''), while under others it is not (''nonopioid''). The existence of these two categories of analgesia leads to the question of how they are related. In a collateral inhibition model proposed by Kirshgessner, Bodnar, and Pasternak (1982), opiate and nonopiate mechanisms were viewed as acting in a mutually inhibitory fashion. In the present experiments, rats were exposed to either of two environmental stressors that produce a nonopioid stress-induced analgesia (SIA) following injections of the opiate antagonist naltrexone or agonist morphine. In the presence of naltrexone, SIA produced by either cold water swim (CWS) or social defeat was enhanced. These same SIAs were found to attenuate the analgesic effect of morphine, demonstrating that an activation of opioid systems can inhibit nonopioid analgesias. These results support an inhibitory interaction of opioid and nonopioid mechanisms in some forms of stress-induced analgesia.