Sweat as an Efficient Natural Moisturizer
Sweat as an Efficient Natural Moisturizer
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DOI：
10.1159/000446756
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发表时间：
2016-01-01
期刊：
影响因子：
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通讯作者：
Mizukawa, Yoshiko
中科院分区：
文献类型：
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作者：
Shiohara, Tetsuo;Sato, Yohei;Mizukawa, Yoshiko
虽然最近对过敏性皮肤病（如特应性皮炎）发病机制的研究主要集中在维持皮肤屏障功能的重要皮肤基因缺陷上，但分泌的汗液具有极大的增加皮肤表面水合作用的能力，并含有保湿因子，这一事实长期被忽视：这些基因缺陷引起的水分流失增加理论上可以通过出汗的显著增加来完全补偿。在这篇综述中，基于最近对汗液生理功能的发现、新认识的汗腺/导管相关皮肤疾病以及这些疾病的治疗方法，对汗液在这些疾病中有害作用的教条提出了挑战。我们现在开始认识到汗腺/汗管是一个复杂的调节系统。此外，根据其解剖位置和损伤程度的不同，该系统可能具有不同的功能：位于躯干和四肢等毛状皮肤褶皱处的汗腺/导管的出汗反应可以作为静止基础条件下维持皮肤水合的天然调节剂，此外还有研究得更好的热调节功能，主要由脊处的热调节功能介导。在各种炎症性皮肤病中，汗液的正常功能会受到干扰。因此，我们应该认识到出汗障碍是这些疾病发展的一个病因因素。(C) 2016 S. Karger AG，巴塞尔
Although recent research on the pathogenesis of allergic skin diseases such as atopic dermatitis has focused on defects in skin genes important for maintaining skin barrier function, the fact that excreted sweat has an overwhelmingly great capacity to increase skin surface hydration and contains moisturizing factors has long been ignored: the increase in water loss induced by these gene defects could theoretically be compensated fully by a significant increase in sweating. In this review, the dogma postulating the detrimental role of sweat in these diseases has been challenged on the basis of recent findings on the physiological functions of sweat, newly recognized sweat gland-/duct-related skin diseases, and therapeutic approaches to the management of these diseases. We are now beginning to appreciate that sweat glands/ducts are a sophisticated regulatory system. Furthermore, depending on their anatomical location and the degree of the impairment, this system might have a different function: sweating responses in sweat glands/ducts located at the folds in hairy skin such as on the trunk and extremities could function as natural regulators that maintain skin hydration under quiescent basal conditions, in addition to the better-studied thermoregulatory functions, which can be mainly mediated by those at the ridges. The nor-mal functioning of sweat could be disturbed in various inflammatory skin diseases. Thus, we should recognize sweating disturbance as an etiologic factor in the development of these diseases. (C) 2016 S. Karger AG, Basel