Spinal projections of the A5, A6 (locus coeruleus), and A7 noradrenergic cell groups in rats.
Spinal projections of the A5, A6 (locus coeruleus), and A7 noradrenergic cell groups in rats.
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DOI：
10.1002/cne.23024
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发表时间：
2012-06-15
期刊：
影响因子：
--
通讯作者：
Saper CB
中科院分区：
文献类型：
--
作者：
Bruinstroop E;Cano G;Vanderhorst VG;Cavalcante JC;Wirth J;Sena-Esteves M;Saper CB
脑桥去甲肾上腺素能细胞群，A5，A6（蓝斑），和A7，提供了唯一的去甲肾上腺素能神经支配的脊髓，但这些群体的每一个区域神经支配的脊髓的个人贡献仍然存在争议。我们已经使用了一种腺相关病毒（AAV）载体编码绿色荧光蛋白下的人工多巴胺β-羟化酶（PRSx 8）启动子，跟踪脊髓的预测从A5，A6和A7组。来自所有三个组的投射在侧索和腹索以及背角的背侧表面中穿过脊髓，但是A6轴突主要采取背侧和腹侧路线，而A5和A7轴突主要采取侧路线。A6组在所有水平提供了致密的神经支配，包括脊髓灰质的所有部分，但在背角中特别致密。A7组提供了下一个最密集的神经支配，再次包括脊髓的所有部分，但它在腹角更密集。A5组仅向背角和腹角以及颈和腰骶水平提供稀疏的神经支配，但向胸中间外侧细胞柱，特别是交感节前神经元提供密集的神经支配。因此，脑桥去甲肾上腺素能细胞群以大致地形和互补的方式投射到脊髓上。观察到的脊髓投射模式表明，蓝斑可能对体感传递的影响最大，A7组对运动功能的影响最大，A5组对交感神经功能的影响最大。
The pontine noradrenergic cell groups, A5, A6 (locus coeruleus), and A7, provide the only noradrenergic innervation of the spinal cord, but the individual contribution of each of these populations to the regional innervation of the spinal cord remains controversial. We have used an adeno-associated viral (AAV) vector encoding green fluorescent protein under an artificial dopamine beta-hydroxylase (PRSx8) promoter, to trace the spinal projections from the A5, A6, and A7 groups. Projections from all three groups travel through the spinal cord in both the lateral and ventral funiculi and in the dorsal surface of the dorsal horn, but A6 axons take predominantly the dorsal and ventral routes whereas A5 and A7 axons take a predominantly lateral route. The A6 group provides the densest innervation at all levels, and includes all parts of the spinal gray matter, but it is particularly dense in the dorsal horn. The A7 group provides the next most dense innervation, again including all parts of the spinal cord, but is it denser in the ventral horn. The A5 group supplies only sparse innervation to the dorsal and ventral horns and to the cervical and lumbosacral levels, but provides the densest innervation to the thoracic intermediolateral cell column, and in particular to the sympathetic preganglionic neurons. Thus, the pontine noradrenergic cell groups project in a roughly topographic and complementary fashion onto the spinal cord. The pattern of spinal projections observed suggests that the locus coeruleus might have the greatest effect on somatosensory transmission, the A7 group on motor function, and the A5 group on sympathetic function.
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