The evolving HIV epidemic and its impact on the HIV testing algorithm: Is it time to change the HIV testing algorithm in South Africa
The evolving HIV epidemic and its impact on the HIV testing algorithm: Is it time to change the HIV testing algorithm in South Africa
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DOI：
10.1016/j.jcv.2021.104990
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发表时间：
2021-10-02
影响因子：
8.8
通讯作者：
Adu-Gyamfi, Clement Gascua
中科院分区：
文献类型：
--
作者：
Mashishi, Bonolo Rankotsane;Makatini, Zinhle;Adu-Gyamfi, Clement Gascua
ABSTR A C T HIV-1/2检测是确保HIV感染者得到诊断和适当管理的第一步。次优HIV-1/2检测算法的影响显著导致了HIV感染误诊率的增加。最近，世界卫生组织（世卫组织）建议高负担国家在不断演变的艾滋病毒流行情况下，将其检测算法从2次检测改为3次检测。新的艾滋病毒检测算法的实施必须在国家框架内量身定制，必须与操作可行性、患者结果和成本效益相平衡。在这次审查中，我们提供了一个概述的艾滋病毒流行病的现状及其对艾滋病毒检测的影响，进一步我们强调关注的领域，从2步到3步测试算法的背景下，南非的艾滋病毒流行病和公共卫生计划。
ABSTR A C T HIV-1/2 testing is the first step in ensuring HIV-infected individuals are diagnosed and appropriately managed. The impact of suboptimal HIV-1/2 testing algorithms significantly contributes to the increased rates of misdi-agnosis of HIV infection. Recently, the World Health Organization (WHO) recommended that high burden countries revise their testing algorithm from a 2 to 3-test testing strategy in the context of an evolving HIV epidemic. Implementation of a new HIV-testing algorithm must be tailor-made within a national framework and must be balanced out with operational feasibility, patient outcomes, and cost-effectiveness. In this review, we provide an overview of the current state of the HIV epidemic and its impact on HIV testing, further we highlight areas of concern in changing from a 2-step to a 3-step test algorithm in the context of South Africa's HIV epidemic and public health program.