Stiffness of the gerbil basilar membrane: Radial and longitudinal variations
Stiffness of the gerbil basilar membrane: Radial and longitudinal variations
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DOI：
10.1152/jn.00446.2003
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发表时间：
2004-01-01
影响因子：
2.5
通讯作者：
Dallos, P
中科院分区：
文献类型：
--
作者：
Emadi, G;Richter, CP;Dallos, P
哺乳动物耳蜗组织的机械性能的实验数据是必不可少的理解频率和位置依赖的运动模式，导致在传入的声波响应。在耳蜗内，由声音引起的振动通过Corti器官转换成神经活动，其总体运动取决于下面的基底膜的运动。在这项研究中，我们提出了在耳蜗横截面内的多个位置和沿着耳蜗长度的多个位置测量的沙鼠基底膜刚度的数据。使用相对简单的耳蜗力学模型对这些数据进行基本分析，揭示了我们最重要的结果：实验测量的基底膜梳状区中部的纵向刚度梯度（4.43 dB/mm）可以解释最佳频率沿着耳蜗长度的变化。此外，我们的研究结果表明，作为径向位置的函数的刚度偏转曲线的定性变化，特别是，有不同的刚度增长率与组织偏转的增加。纵向耦合内的基底膜/器官的Corti复杂的确定有一个空间常数为21妈妈在中间转向的耳蜗。我们的大部分数据是在hemicobacteria制备中获得的，我们将这组数据与体内获得的数据进行了比较。
Experimental data on the mechanical properties of the tissues of the mammalian cochlea are essential for understanding the frequency- and location-dependent motion patterns that result in response to incoming sound waves. Within the cochlea, sound-induced vibrations are transduced into neural activity by the organ of Corti, the gross motion of which is dependent on the motion of the underlying basilar membrane. In this study we present data on stiffness of the gerbil basilar membrane measured at multiple positions within a cochlear cross section and at multiple locations along the length of the cochlea. A basic analysis of these data using relatively simple models of cochlear mechanics reveals our most important result: the experimentally measured longitudinal stiffness gradient at the middle of the pectinate zone of the basilar membrane (4.43 dB/mm) can account for changes of best frequency along the length of the cochlea. Furthermore, our results indicate qualitative changes of stiffness-deflection curves as a function of radial position; in particular, there are differences in the rate of stiffness growth with increasing tissue deflection. Longitudinal coupling within the basilar membrane/organ of Corti complex is determined to have a space constant of 21 mum in the middle turn of the cochlea. The bulk of our data was obtained in the hemicochlea preparation, and we include a comparison of this set of data to data obtained in vivo.