Involvement of Panton-Valentine leukocidin-producing Staphylococcus aureus in primary skin infections and pneumonia
Involvement of Panton-Valentine leukocidin-producing Staphylococcus aureus in primary skin infections and pneumonia
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DOI：
10.1086/313461
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发表时间：
1999-11-01
影响因子：
11.8
通讯作者：
Etienne, J
中科院分区：
文献类型：
--
作者：
Lina, G;Piémont, Y;Etienne, J
潘顿瓦伦丁杀白细胞素 (PVL) 是一种细胞毒素，可导致白细胞破坏和组织坏死。它是由不到 5% 的金黄色葡萄球菌菌株产生的。通过聚合酶链式反应扩增筛选了 172 株金黄色葡萄球菌菌株的 PVL 基因。在 93% 与疖病相关的菌株和 85% 与严重坏死性出血性肺炎相关的菌株（均为社区获得性）中检测到 PVL 基因。在 55% 的蜂窝组织炎菌株、50% 的皮肤脓肿菌株、23% 的骨髓炎菌株和 13% 的指髓感染菌株中检测到它们。在导致其他感染的菌株中未检测到PVL基因，例如感染性心内膜炎、纵隔炎、医院获得性肺炎、尿路感染和小肠结肠炎，或与中毒性休克综合征相关的菌株。因此，PVL 主要与涉及皮肤或粘膜的坏死性病变有关。
Panton-Valentine leukocidin (PVL) is a cytotoxin that causes leukocyte destruction and tissue necrosis. It is produced by fewer than 5% of Staphylococcus aureus strains. A collection of 172 S. aureus strains were screened for PVL genes by polymerase chain reaction amplification. PVL genes were detected in 93% of strains associated with furunculosis and in 85% of those associated with severe necrotic hemorrhagic pneumonia (all community-acquired). They were detected in 55% of cellulitis strains, 50% of cutaneous abscess strains, 23% of osteomyelitis strains, and 13% of finger-pulp-infection strains. PVL genes were not detected in strains responsible for other infections, such as infective endocarditis, mediastinitis, hospital-acquired pneumonia, urinary tract infection, and enterocolitis, or in those associated with toxic-shock syndrome. It thus appears that PVL is mainly associated with necrotic lesions involving the skin or mucosa.