Near-Infrared Light-Triggered Sulfur Dioxide Gas Therapy of Cancer
Near-Infrared Light-Triggered Sulfur Dioxide Gas Therapy of Cancer
复制标题
近红外光引发的二氧化硫气体治疗癌症
DOI：
10.1021/acsnano.8b08700
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发表时间：
2019-02-01
期刊：
影响因子：
17.1
通讯作者：
Yang, Huanghao
中科院分区：
文献类型：
--
作者：
Li, Shihua;Liu, Rui;Yang, Huanghao
利用气体治疗平台作为选择性癌症治疗的“绿色”方法具有很大的前景，然而，它往往伴随着一些挑战，例如气体产生不受控制或不足以及治疗机制不明确。本研究开发了一种基于近红外（NIR）光触发二氧化硫（SO2）生成的气体治疗方法，并证明了其治疗机制和体内抗肿瘤治疗效果。构建了一种载SO2前药的摇状结构upconversion@silica纳米颗粒（RUCSNs），其载药量大且无明显泄漏，并将近红外光转化为紫外光，从而激活前药生成SO2。此外，SO2前药负载的RUCSNs具有高细胞摄取、良好的生物相容性、细胞内跟踪能力和高近红外光触发的细胞毒性。此外，发现细胞毒性SO2诱导细胞凋亡，并伴有细胞内活性氧水平升高和核DNA损伤。此外，有效抑制了肿瘤生长，显著延长了小鼠的生存期。这种近红外光触发的二氧化硫治疗可能为促进协同癌症治疗平台的进一步发展提供有效的策略。
The exploitation of gas therapy platforms holds great promise as a "green" approach for selective cancer therapy, however, it is often associated with some challenges, such as uncontrolled or insufficient gas generation and unclear therapeutic mechanisms. In this work, a gas therapy approach based on near infrared (NIR) light-triggered sulfur dioxide (SO2) generation was developed, and the therapeutic mechanism as well as in vivo antitumor therapeutic efficacy was demonstrated. A SO2 prodrug-loaded rattle-structured upconversion@silica nanoparticles (RUCSNs) was constructed to enable high loading capacity without obvious leakage and to convert NIR light into ultraviolet light so as to activate the prodrug for SO2 generation. In addition, SO2 prodrug-loaded RUCSNs showed high cell uptake, good biocompatibility, intracellular tracking ability, and high NIR light-triggered cytotoxicity. Furthermore, the cytotoxic SO2 was found to induce cell apoptosis accompanied by the increase of intracellular reactive oxygen species levels and the damage of nuclear DNA. Moreover, efficient inhibition of tumor growth was achieved, associated with significantly prolonged survival of mice. Such NIR light-triggered SO2 therapy may provide an effective strategy to stimulate further development of synergistic cancer therapy platforms.