The catastrophe revisited: Blood compatibility in the 21st century
The catastrophe revisited: Blood compatibility in the 21st century
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DOI：
10.1016/j.biomaterials.2007.07.035
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发表时间：
2007-12-01
期刊：
影响因子：
14
通讯作者：
Ratner, Buddy D.
中科院分区：
文献类型：
--
作者：
Ratner, Buddy D.
生物材料界一直无法准确地分配术语“血液相容”的生物材料，尽管50年的深入研究的主题。对于哪些材料是“血液相容性”，没有明确的共识。“没有标准化的方法来评估血液相容性。由于我们每年使用数以百万计的与血液接触的设备，我们必须认真考虑这场智力灾难。从这个角度来看，我认为五个假设，为什么进展缓慢，在发展一个清晰的理解血液相容性：假设1-这是不可能的，使血液相容性材料。假设2-我们不了解血液相容性背后的生物学。假设3-我们不知道如何测试或评估血液相容性。假设4-某些天然来源的材料似乎显示出更好的血液相容性，但我们不知道如何利用这一概念。假设5-我们现在有更好的血液相容性材料，但监管和经济环境阻碍了临床实践的采用。(C)2007爱思唯尔有限公司保留所有权利。
The biomaterials community has been unable to accurately assign the term "blood compatible" to a biomaterial in spite of 50 years of intensive research on the subject. There is no clear consensus as to which materials are "blood compatible." There are no standardized methods to assess blood compatibility. Since we use millions of devices in contact with blood each year, it is imperative we give serious thought to this intellectual catastrophe. In this perspective, I consider five hypotheses as to why progress has been slow in evolving a clear understanding of blood compatibility: Hypothesis 1-It is impossible to make a blood compatible material. Hypothesis 2-We do not understand the biology behind blood compatibility. Hypothesis 3-We do not understand how to test for or evaluate blood compatibility. Hypothesis 4-Certain materials of natural origin seem to show better blood compatibility but we do not know how to exploit this concept. Hypothesis 5-We now have better blood compatible materials but the regulatory and economic climate prevent adoption in clinical practice. (C) 2007 Elsevier Ltd. All rights reserved.