Peptidome Analysis of Human Serum From Normal and Preeclamptic Pregnancies
Peptidome Analysis of Human Serum From Normal and Preeclamptic Pregnancies
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正常和先兆子痫妊娠人血清的肽组分析
DOI：
10.1002/jcb.26087
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发表时间：
2017-12-01
影响因子：
4
通讯作者：
Long, Wei
中科院分区：
文献类型：
--
作者：
Dai, Xiaonan;Song, Xuejing;Long, Wei
先兆子痫是一种严重危害孕妇和婴儿健康的疾病。为了更好地了解先兆子痫的分子机制，我们使用液相色谱-质谱/质谱 (LC-MS/MS) 构建了正常妊娠和先兆子痫妊娠之间人血清的比较肽组学分析。总共有 201 种肽被可靠鉴定，其中 21 种上调，3 种下调。进一步分析表明，这些差异表达的肽与先兆子痫病理变化过程中发生的酶调节活性、生物调节和凝血级联相关。血清中关键肽的鉴定不仅可以作为更好地了解和进一步探索PE的病因和发病机制的基础，而且可以作为潜在的生物标志物，并为PE的未来治疗提供靶点，特别是早发性严重PE（sPE）。 J.细胞。生物化学。 118：4341-4348，2017 年。(c) 2017 年 Wiley 期刊公司。
Preeclampsia is a kind of disease that severely harms the health of pregnant women and infants. To better understand the molecular mechanisms involved in preeclampsia, we used liquid chromatography-mass spectrometry/mass spectrometry (LC-MS/MS) to construct a comparative peptidomic profiling of human serum between normal and preeclamptic pregnancies. A total of 201 peptides were confidently identified, with 21 up-regulated and three down-regulated. Further analysis indicated that these differentially expressed peptides correlate with enzyme regulator activity, biological regulation, and coagulation cascades occurring during pathological changes of preeclampsia. The identification of key peptides in serum may serve not only as a basis for better understanding and further exploring the etiology and pathogenesis of PE, but also as potential biomarkers and in providing targets for future therapy in PE, especially in early onset severe PE (sPE). J. Cell. Biochem. 118: 4341-4348, 2017. (c) 2017 Wiley Periodicals, Inc.