Dual modal fluorescent colposcope combined with near-infrared fluorescent dye TMTP1-PEG4-ICG to detect cervical lesions
Dual modal fluorescent colposcope combined with near-infrared fluorescent dye TMTP1-PEG4-ICG to detect cervical lesions
复制标题
双模态荧光阴道镜联合近红外荧光染料TMTP1-PEG4-ICG检测宫颈病变
DOI：
10.1364/boe.410394
复制
发表时间：
2020-12-01
影响因子：
3.4
通讯作者：
Lu, Jinling
中科院分区：
文献类型：
--
作者：
Wang, Chen;Zhou, Ying;Lu, Jinling
为了利用肿瘤靶向近红外（NIR）荧光染料TMTP 1-PEG 4-ICG检查宫颈病变，开发了具有可见反射成像和荧光成像的双模阴道镜。通过设计特殊的光学系统，采用双传感器CCD摄像头，将近红外荧光成像和可见光反射成像集成在阴道镜上。使用该双模式阴道镜检查鳞状细胞癌、腺癌、宫颈上皮内瘤变（CIN）和宫颈炎患者，以验证其检测宫颈癌的潜力。在检查前30分钟将荧光染料TMTP 1-PEG 4-ICG应用于宫颈。用生理盐水擦拭未结合的荧光染料后收集荧光图像。分析荧光图像的信号反比（SBR），并与组织学分析进行比较。提示荧光阴道镜联合肿瘤特异性近红外荧光染料TMTP 1-PEG 4-ICG有助于真实的实时评价宫颈病变。(C)根据OSA开放获取出版协议的条款，2020年美国光学学会
To examine the cervical lesions by using the tumor-targeted near-infrared (NIR) fluorescent dyes TMTP1-PEG4-ICG, a dual modal colposcope with visible reflectance imaging and fluorescence imaging was developed. NIR fluorescence imaging and visible light reflectance imaging were integrated together on a colposcope by designing the specific optics and adopting a dual sensor charge coupled device (CCD) camera. Patients with squamous cell carcinoma, adenocarcinoma, cervical intraepithelial neoplasia (CIN) and cervicitis were examined using this dual modal colposcope to validate its potential of cervical cancer detection. Fluorescent dye TMTP1-PEG4-ICG was applied to the cervix 30 minutes before inspection. The fluorescence images were collected after wiping the unbound fluorescent dye using normal saline. Signal to back ratios (SBR) of the fluorescence images were analyzed and compared with the histological analysis. The results suggest that the fluorescent colposcope combined with tumor-specific near-infrared fluorescent dyes TMTP1-PEG4-ICG could help to evaluate cervical lesions in real time. (C) 2020 Optical Society of America under the terms of the OSA Open Access Publishing Agreement