A review of micro- and macrovascular analyses in the assessment of tumor-associated vasculature as visualized by MR
A review of micro- and macrovascular analyses in the assessment of tumor-associated vasculature as visualized by MR
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DOI：
10.1016/j.neuroimage.2007.03.067
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发表时间：
2007-01-01
期刊：
影响因子：
5.7
通讯作者：
Smith, J. Keith
中科院分区：
文献类型：
--
作者：
Bullitt, Elizabeth;Reardon, David A.;Smith, J. Keith
目前还没有非侵入性的、可靠的方法来评估脑肿瘤的恶性程度或监测肿瘤的治疗反应。监测肿瘤血管的变化可能为评估肿瘤侵袭性和治疗效果提供一种有效的手段。到目前为止，大多数这样的研究都集中在肿瘤的微血管成像上，渗透性和/或灌注成像用于评估亚体素水平的血管变化。另一种方法是在“宏观”水平上评估肿瘤血管，计算可通过磁共振血管成像区分的较大血管的数量和形状。本文从微观(动态MR灌注和通透性)和宏观(MR血管成像)两个层面对磁共振血管成像进行了综述。这两种方法提供了不同的、互补的信息，共同提供了对癌症生长的重要见解，以及评估恶性肿瘤和肿瘤治疗反应的新方法。
There is currently no noninvasive, reliable method of assessing brain tumor malignancy or of monitoring tumor treatment response. Monitoring changes to tumor vasculature might provide an effective means of assessing both tumor aggressiveness and treatment efficacy. To date, most such research has concentrated upon tumor "micro-vascular" imaging, with permeability and/or perfusion imaging used to assess vessel changes at the subvoxel level. An alternative approach assesses tumor vasculature at the "macroscopic" level, calculating the numbers and shapes of the larger vessels discriminable by magnetic resonance angiography. This paper provides an overview of magnetic resonance (MR) vascular imaging at both the microscopic (dynamic MR perfusion and permeability) and macroscopic (MR angiographic) levels. The two approaches provide different, complementary information and together could provide important insights into cancer growth as well as new methods of assessing malignancy and tumor treatment response.