DIRECTIONAL NON-CELL AUTONOMY AND THE TRANSMISSION OF POLARITY INFORMATION BY THE FRIZZLED GENE OF DROSOPHILA
DIRECTIONAL NON-CELL AUTONOMY AND THE TRANSMISSION OF POLARITY INFORMATION BY THE FRIZZLED GENE OF DROSOPHILA
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DOI：
10.1038/329549a0
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发表时间：
1987-10-08
期刊：
影响因子：
64.8
通讯作者：
ADLER, PN
中科院分区：
文献类型：
--
作者：
VINSON, CR;ADLER, PN
卷曲（fz）位点的功能对于黑腹果蝇成体角质层上平行排列的刚毛和毛发的发育是必需的1,2。从5个等位基因中产生了标记有丝分裂克隆，并在翅膀中进行了检测。三个等位基因具有非细胞自主的毛发极性表型；野生型细胞远端克隆产生具有异常极性的毛发。相反，其他两个等位基因的克隆不会破坏相邻细胞的极性。这些数据表明，在翅膀上建立毛发极性的过程中，fz2有两种不同的功能。其中一个功能涉及沿机翼近端-远端轴的透射率和/或极性信号的产生。第二个功能涉及极性信号的细胞解释。
The function of thefrizzled(fz) locus is required for the development of a parallel array of bristles and hairs on the adult cuticle ofDrosophila melanogaster1,2. Markedfzmitotic clones from five alleles were generated and examined in the wing. Three alleles have a non-cell-autonomous hair polarity phenotype; wild-type cells distal tofzclones produce hairs that have an abnormal polarity. In contrast,fzclones of the other twofzalleles examined do not disrupt the polarity of neighbouring cells. These data suggest thatfzhas two mutably separate functions in establishing hair polarity on the wing. One function involves the transmittance and/or generation of a polarity signal along the proximal-distal axis of the wing. The second function involves the cellular interpretation of a polarity signal.