Visual experience-dependent maturation of correlated neuronal activity patterns in a developing visual system.
Visual experience-dependent maturation of correlated neuronal activity patterns in a developing visual system.
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DOI：
10.1523/jneurosci.5802-10.2011
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发表时间：
2011-06-01
期刊：
影响因子：
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通讯作者：
Aizenman CD
中科院分区：
文献类型：
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作者：
Xu H;Khakhalin AS;Nurmikko AV;Aizenman CD
随着发育，神经回路的功能特性变得越来越强大。这使得电路可以根据各种输入优化其输出。然而，目前尚不清楚这种优化是否是硬连线电路元件的功能，或者是否需要神经经验才能发展。在这里，我们对非洲爪蟾视神经顶盖中体积标记神经元的钙信号进行快速体内成像，以解决发育中的顶盖神经元群体对视觉刺激的快速时空响应特性。我们发现，在技术发展的关键时期，网络活动变得越来越健壮，更加相关和同步。这些发育变化在发育过程中需要正常的视觉输入，并被NMDA受体阻断。我们的数据表明，视觉活动和NMDAR激活对视觉系统发展过程中顶叶网络动态的成熟至关重要。
The functional properties of neural circuits become increasingly robust over development. This allows circuits to optimize their output in response to a variety of input. However it is not clear whether this optimization is a function of hardwired circuit elements, or whether it requires neural experience in order to develop. Here we perform rapid in vivo imaging of calcium signals from bulk-labeled neurons in the Xenopus laevis optic tectum in order to resolve the rapid spatiotemporal response properties of populations of developing tectal neurons in response to visual stimuli. We find that during a critical time in tectal development, network activity becomes increasingly robust, more correlated and more synchronous. These developmental changes require normal visual input during development and are disrupted by NMDA receptor blockade. Our data show that visual activity and NMDAR activation are critical for the maturation of tectal network dynamics during visual system development.