Impact of Pre-Transplant Malignancy on Outcomes After Kidney Transplantation: United Network for Organ Sharing Database Analysis
Impact of Pre-Transplant Malignancy on Outcomes After Kidney Transplantation: United Network for Organ Sharing Database Analysis
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DOI：
10.1016/j.jamcollsurg.2019.06.001
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发表时间：
2019-12-01
影响因子：
5.2
通讯作者：
Wilke, Lee G.
中科院分区：
文献类型：
--
作者：
Livingston-Rosanoff, Devon;Foley, David P.;Wilke, Lee G.
背景：有移植前恶性肿瘤（pre-TM）病史的肾移植受者发生移植后恶性肿瘤（post-TM）的风险增加，长期预后可能较差。目前还没有大型数据库研究对这类患者与未患tm前患者的现代趋势和结果进行了比较。研究设计：在联合器官共享网络（UNOS）数据库中查询患有pre-TM的原发性成人肾移植受者。采用多变量Cox比例风险分析（n = 170,684）比较2004年至2016年pre-TM患者和未pre-TM患者的结果。结果：前tm患者的肾移植率比
BACKGROUND: Kidney transplant recipients with a history of a pre-transplant malignancy (pre-TM) have an increased risk of post-transplant malignancies (post-TM) and suspected inferior long-term outcomes. No large database studies have examined modern day trends and outcomes in this patient population compared with those without a pre-TM.STUDY DESIGN: The United Network for Organ Sharing (UNOS) database was queried for primary adult kidney transplant recipients with pre-TM. Outcomes were compared in patients with and without pre-TM from 2004 to 2016 using multivariable Cox proportional hazard analyses (n = 170,684).RESULTS: The rate of kidney transplants in patients with pre-TM increased from