Intermittent long-term shedding and induction of carrier birds after infection of chickens early posthatch with a low or high dose of Salmonella enteritidis.
Intermittent long-term shedding and induction of carrier birds after infection of chickens early posthatch with a low or high dose of Salmonella enteritidis.
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DOI：
10.1093/ps/83.11.1911
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发表时间：
2004-11
期刊：
影响因子：
4.4
通讯作者：
F. Immerseel;J. D. Buck;F. Pasmans;L. Bohez;F. Boyen;Freddy Haesebrouck;Richard Ducatelle
中科院分区：
文献类型：
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作者：
F. Immerseel;J. D. Buck;F. Pasmans;L. Bohez;F. Boyen;Freddy Haesebrouck;Richard Ducatelle
由于环境污染，家禽很可能在产后早期感染沙门氏菌。本研究旨在评价感染剂量对蛋鸡持续感染风险的影响。在本研究中，雏鸡口服感染低剂量（产后1天10(2)cfu）或高剂量（产后1周10(9)cfu）肠炎沙门氏菌。观察排便模式和持续时间为18周。所有鸡感染沙门氏菌后均早期脱落，且在整个研究期间呈间歇性脱落。在沙门氏菌暴露后的第一周内，高剂量组的阳性鸟类多于低剂量组。然而，从感染后10周开始，口服感染低剂量肠炎沙门氏菌的鸟类比口服感染高剂量肠炎沙门氏菌的鸟类排出的沙门氏菌更多。在18周龄时，治疗组之间盲肠定植没有差异。由此可见，雏鸡感染低剂量肠炎沙门氏菌可导致持续感染，直至产蛋，从而间歇性排出沙门氏菌。
Poultry are very likely to become infected with Salmonella in the early posthatch period, due to environmental contamination. The purpose of this study was to evaluate the effect of infection dose on the risk of persistent infection in laying hens. In this study, young layer chicks were orally infected with a low (10(2) at 1 d posthatch) or a high dose (10(9) cfu at 1 wk posthatch) of Salmonella Enteritidis. The pattern and duration of fecal shedding was studied for 18 wk. All chickens shed Salmonella early after infection and shed Salmonella intermittently during the whole study period. There were more positive birds in the high-dose group than in the low-dose group in the first weeks following Salmonella exposure. From 10 wk postinfection onwards, however, birds that were orally infected with the low dose of Salmonella Enteritidis shed more Salmonella than the birds that received the high dose. At 18 wk of age, there was no difference in cecal colonization between the treatment groups. It can be concluded that infection of newly hatched chicks with a low dose of Salmonella Enteritidis can lead to persistent infection until onset of lay, hereby excreting Salmonella bacteria intermittently.