Long-term remissions of young patients with high-risk follicular lymphoma after first-line autologous stem cell transplantation Three case reports
Long-term remissions of young patients with high-risk follicular lymphoma after first-line autologous stem cell transplantation Three case reports
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年轻高危滤泡性淋巴瘤患者一线自体干细胞移植后长期缓解3例报告
DOI：
10.1097/md.0000000000020395
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发表时间：
2020
期刊：
影响因子：
1.6
通讯作者：
Qiu Lugui
中科院分区：
文献类型：
--
作者：
Lyu Rui;Wang Tingyu;Zou Dehui;Liu Wei;Yi Shuhua;Huang Wenyang;An Gang;Xu Yan;Li Zengjun;Qiu Lugui
干预：3例患者接受联合化疗加利妥昔单抗治疗，然后进行一线ASCT治疗。结果：3例患者ASCT后均获完全缓解，残留病变极少，中位随访时间109(97~117)个月，移植后8年以上全部缓解。对于患有某些高危FL的年轻患者，一线ASCT并不违反指南，应个别推荐。
Interventions:The 3 patients received combined chemotherapy plus rituximab, followed by first-line ASCT.Outcomes:All the 3 patients got complete remission and minimal residual disease negativity after ASCT, The median follow-up time was 109 (97–117) months, and all of them were in remission more than 8 years after transplant.Lessons:Guidelines for FL are mainly based on elderly patients, but are not suitable enough for all, especially for the young FL patients. For young patients with certain high-risk FL, first-line ASCT does not go against the guidelines, and should be recommended individually.