Boron Catalysis in the Transformation of Carboxylic Acids and Carboxylic Acid Derivatives
Boron Catalysis in the Transformation of Carboxylic Acids and Carboxylic Acid Derivatives
复制标题
硼催化羧酸及羧酸衍生物的转化
DOI：
10.1002/ejoc.202201249
复制
发表时间：
2022
影响因子：
2.8
通讯作者：
Shimizu Yohei
中科院分区：
文献类型：
--
作者：
Sawamura Masaya;Shimizu Yohei
羧酸、酰胺和酯是功能有机分子中普遍存在的基序。然而，这些高氧化态羰基化合物的反应性远低于酮和醛，并且适用于转化这类羰基化合物的催化剂有限。另一方面，硼催化剂通过利用其空位p轨道的独特性质，在羰基化合物的转化中发现了各种应用。在过去的十年中，硼催化剂的不断进步已经实现了羧酸、酰胺和酯的几种前所未有的直接转化。本文根据反应类型，重点介绍了硼催化在非活化羧酸、酰胺和酯中的应用，并对硼催化的代表性成果进行了综述。
Carboxylic acids, amides, and esters are ubiquitous motifs in functional organic molecules. However, the reactivities of these high oxidation state carbonyl compounds are far lower than ketones and aldehydes, and catalysts applicable to transform this class of carbonyl compounds are limited. On the other hand, boron catalysts have found various applications in the transformation of carbonyl compounds by taking advantage of the unique properties derived from their vacantp‐orbitals. The continuous advancement of boron catalysis has realized several unprecedented direct transformations of carboxylic acids, amides, and esters in the past decade. In this review, representative achievements of boron catalysis are summarized according to reaction types by focusing on their applications to non‐activated carboxylic acids, amides, and esters.