A meta-analysis of the risk of boys with isolated cryptorchidism developing testicular cancer in later life
A meta-analysis of the risk of boys with isolated cryptorchidism developing testicular cancer in later life
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DOI：
10.1136/archdischild-2012-302051
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发表时间：
2013-01-01
影响因子：
5.2
通讯作者：
Carachi, Robert
中科院分区：
文献类型：
--
作者：
Lip, Stefanie Zhao Lin;Murchison, Louise Elizabeth Denheen;Carachi, Robert
背景孤立性隐睾患者睾丸恶性肿瘤的相对危险度（RR）存在显著的变异性。目的进行荟萃分析，以阐明这种风险的真实程度，使临床医生能够更好地为患者及其家属提供咨询。使用Embase和Medline数据库检索1980年1月1日至2010年12月31日期间发表的与睾丸癌和隐睾症相关的英文文献。根据我们的纳入和排除标准，由四位作者独立识别和分析了735篇论文。研究报告隐睾症和睾丸恶性肿瘤的后续发展之间的关联被纳入。遗传综合征或其他易发生隐睾的疾病被排除在外。结果共纳入9个病例对照研究和3个队列研究。病例对照研究包括2281例病例和4811例对照。队列研究纳入了2177941名男孩，共有345名男孩发生睾丸癌（总随访时间为58270679人年）。合并RR为2.90（95%CI 2.21 - 3.82），具有显著异质性（p
Background Significant variability exists for the relative risk (RR) of testicular malignancy in isolated cryptorchidism.Objective To perform a meta-analysis to clarify the true magnitude of this risk, allowing clinicians to better counsel patients and their families.Setting Secondary research conducted by undergraduate researchers, clinical academics and a clinical statistician.Design, data sources, and methods A search of the English literature was performed for studies relating to testicular cancer and cryptorchidism, published between 1 January 1980 and 31 December 2010, using Embase and Medline databases. 735 papers were identified and analysed by four authors independently in accordance with our inclusion and exclusion criteria. Studies reporting an association between cryptorchidism and subsequent development of testicular malignancy were included. Genetic syndromes or other conditions which predisposed to the development of cryptorchidism were excluded. Pooled estimates and 95% CIs for the RRs were calculated.Results Nine case-control studies and three cohort studies were selected. The case-control studies included 2281 cases and 4811 controls. Cohort studies included 2 177 941 boys, with a total of 345 boys developing testicular cancer (total length of follow-up was 58 270 679 person-years). The pooled RR was 2.90 (95% CI 2.21 to 3.82) with significant heterogeneity (p