Knee Cartilage Thickness, T1ρ and T2 Relaxation Time Are Related to Articular Cartilage Loading in Healthy Adults.
Knee Cartilage Thickness, T1ρ and T2 Relaxation Time Are Related to Articular Cartilage Loading in Healthy Adults.
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DOI：
10.1371/journal.pone.0170002
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发表时间：
2017
期刊：
影响因子：
3.7
通讯作者：
Jonkers I
中科院分区：
文献类型：
--
作者：
Van Rossom S;Smith CR;Zevenbergen L;Thelen DG;Vanwanseele B;Van Assche D;Jonkers I
腕关节对周期性日常活动期间施加的负荷有反应。然而，软骨的厚度分布和生化成分与行走过程中的局部接触压力之间的局部关系尚未建立。本研究的目的是评估软骨厚度，蛋白多糖和胶原蛋白浓度之间的关系，在膝关节和膝关节负荷的接触力和压力在步行过程中。采集15名健康受试者的3D步态分析和MRI（3D-FSE、T1ρ弛豫时间和T2弛豫时间序列）。实验步态数据进行处理，使用肌肉骨骼建模，计算接触力，脉冲和压力分布在胫股关节。检查局部软骨厚度与股骨髁负重区平均T1ρ和T2弛豫时间的相关性。局部厚度与局部压力显著相关：站立时内侧厚度与内侧髁接触压力和接触力相关，外侧髁厚度与外侧髁接触压力和接触力相关。此外，平均T1ρ和T2弛豫时间与峰值接触力和脉冲显著相关。T1ρ弛豫时间增加与剪切载荷增加相关，T1ρ和T2弛豫时间减少与压缩力和压力增加相关。较厚的软骨与行走过程中较高的髁突负荷相关，表明在周期性活动（如步态）期间经历较高负荷的那些区域的软骨厚度增加。此外，从T1ρ和T2弛豫测量得到的蛋白聚糖和胶原蛋白浓度和取向与载荷有关。
Cartilage is responsive to the loading imposed during cyclic routine activities. However, the local relation between cartilage in terms of thickness distribution and biochemical composition and the local contact pressure during walking has not been established. The objective of this study was to evaluate the relation between cartilage thickness, proteoglycan and collagen concentration in the knee joint and knee loading in terms of contact forces and pressure during walking. 3D gait analysis and MRI (3D-FSE, T1ρ relaxation time and T2 relaxation time sequence) of fifteen healthy subjects were acquired. Experimental gait data was processed using musculoskeletal modeling to calculate the contact forces, impulses and pressure distribution in the tibiofemoral joint. Correlates to local cartilage thickness and mean T1ρ and T2 relaxation times of the weight-bearing area of the femoral condyles were examined. Local thickness was significantly correlated with local pressure: medial thickness was correlated with medial condyle contact pressure and contact force, and lateral condyle thickness was correlated with lateral condyle contact pressure and contact force during stance. Furthermore, average T1ρ and T2 relaxation time correlated significantly with the peak contact forces and impulses. Increased T1ρ relaxation time correlated with increased shear loading, decreased T1ρ and T2 relaxation time correlated with increased compressive forces and pressures. Thicker cartilage was correlated with higher condylar loading during walking, suggesting that cartilage thickness is increased in those areas experiencing higher loading during a cyclic activity such as gait. Furthermore, the proteoglycan and collagen concentration and orientation derived from T1ρ and T2 relaxation measures were related to loading.