A POSSIBLE PATHOPHYSIOLOGIC SUBSTRATE OF ATTENTION-DEFICIT HYPERACTIVITY DISORDER
A POSSIBLE PATHOPHYSIOLOGIC SUBSTRATE OF ATTENTION-DEFICIT HYPERACTIVITY DISORDER
复制标题
DOI：
10.1177/0883073891006001s09
复制
发表时间：
1991-01-01
影响因子：
1.9
通讯作者：
NADEAU, SE
中科院分区：
文献类型：
--
作者：
HEILMAN, KM;VOELLER, KKS;NADEAU, SE
注意缺陷多动障碍（ADHD）与注意力缺陷、反应抑制和运动不安有关。注意力不集中，有缺陷的反应抑制和不持久更常见于成人右半球功能障碍而不是左半球功能障碍。鉴于这一事实，并且因为患有多动症的儿童不仅表现出这些症状，而且还忽视了左侧，并且他们的右侧新纹状体的激活减少，我们认为这些儿童有右半球功能障碍。此外，由于多动症儿童以及额叶和纹状体功能障碍的患者和动物都可以看到注意力不集中和有缺陷的反应抑制，我们提出多动症儿童在右侧额纹状体系统中存在功能障碍。运动不安可能反映了由于中皮层多巴胺系统受损而导致的额叶功能障碍。
The attention deficit hyperactivity disorder (ADHD) is associated with defective attention and response inhibition and motor restlessness. Inattention, defective response inhibition, and impersistence are more commonly seen in adults with right than with left hemisphere dysfunction. In light of this fact and because children with ADHD not only appear to demonstrate these symptoms but also neglect the left side and have decreased activation of their right neostriatum, we propose that these children have a right hemisphere dysfunction. In addition, because both inattention and defective response inhibition can be seen in children with ADHD and in patients and animals who have frontal lobe and striatal dysfunction, we propose that children with ADHD have dysfunction in a right-sided frontal-striatal system. Motor restlessness may reflect frontal lobe dysfunction due to impairment of the mesocortical dopamine system.