Young Netherlands Twin Register (Y-NTR): A longitudinal multiple informant study of problem behavior
Young Netherlands Twin Register (Y-NTR): A longitudinal multiple informant study of problem behavior
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DOI：
10.1375/twin.10.1.3
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发表时间：
2007-02-01
影响因子：
0.9
通讯作者：
Boomsma, Dorret I.
中科院分区：
文献类型：
--
作者：
Bartels, Meike;van Beijsterveldtl, C. E. M. (Toos);Boomsma, Dorret I.
荷兰双胞胎登记册 (NTR) 于 1987 年左右在荷兰阿姆斯特丹自由大学成立。本文总结了对双胞胎行为的母亲和父亲评级的纵向遗传分析，作为孩子性别的函数，包括攻击性（AGG）、注意力问题（AP）、焦虑/抑郁（ANX）、内化行为（INT）和外化行为（EXT）。我们发现遗传影响是解释这些性状个体差异的最重要因素。对于大多数表型，遗传因素的影响在整个发育过程中都会波动，但 AP 除外，其遗传影响保持相似的程度。遗传影响的变化与共享环境影响的变化平行，而非共享环境影响则保持相对恒定。大约 10% 到 20% 的差异是由父母特定的共享环境造成的，其中包括评估者偏差。对于所有表型，整个童年时期的稳定性是由遗传和共享的环境因素决定的，而非共享的环境影响主要是年龄/测量特定的。大约 15% 的表型稳定性是由评估者特定的共同环境影响造成的，其中包括评估者偏差。综上所述，3岁至12岁之间遗传因素是造成情绪和行为问题个体差异的最重要原因。
The Netherlands Twin Register (NTR) was established around 1987 at the Vrije Universiteit in Amsterdam, the Netherlands. The current article summarizes the longitudinal genetic analyses of maternal and paternal ratings of twins' behavior as a function of the sex of the children for the traits of aggression (AGG), attention problems (AP), anxious/depression (ANX), internalizing behavior (INT) and externalizing behavior (EXT). We found that genetic influences are the most important factor in explaining individual differences in these traits. For most phenotypes, influences of genetic factors fluctuate throughout development, with the exception of AP, for which genetic influences remain of similar magnitude. Changes in genetic influences parallel those in shared environmental influences, while non-shared environmental influences remain relatively constant. Around 10% to 20% of the variance is accounted for by parent-specific shared environment, which includes rater bias. For all phenotypes, stability throughout childhood is accounted for by genetic and shared environmental factors, while nonshared environmental influences are mainly age/measurement specific. About 15% of the phenotypic stability is accounted for by rater-specific shared environmental influences, which include rater bias. In conclusion, between ages 3 and 12 genetic factors are the most important cause of individual differences in emotional and behavioral problems.