Directed evolution of enzymes and pathways for industrial biocatalysis.
Directed evolution of enzymes and pathways for industrial biocatalysis.
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DOI：
10.1016/s0958-1669(02)00291-4
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发表时间：
2002-04
影响因子：
7.7
通讯作者：
Huimin Zhao;K. Chockalingam;Zhilei Chen
中科院分区：
文献类型：
--
作者：
Huimin Zhao;K. Chockalingam;Zhilei Chen
定向进化已成为开发酶和全细胞生物催化剂的有力工具。最近的重大进展包括创造新的酶功能和开发几种新的有效定向进化方法。定向进化和合理设计的结合有望加速生物催化剂在制药、化学和食品工业中的应用开发。
Directed evolution has become a powerful tool for developing enzyme and whole cell based biocatalysts. Significant recent advances include the creation of novel enzyme functions and the development of several new efficient directed evolution methods. The combination of directed evolution and rational design promises to accelerate the development of biocatalysts for applications in the pharmaceutical, chemical and food industries.