One session of high frequency repetitive transcranial magnetic stimulation (rTMS) to the right prefrontal cortex transiently reduces cocaine craving
One session of high frequency repetitive transcranial magnetic stimulation (rTMS) to the right prefrontal cortex transiently reduces cocaine craving
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DOI：
10.1016/j.drugalcdep.2006.06.002
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发表时间：
2007-01-05
影响因子：
4.2
通讯作者：
Pascual-Leone, Alvaro
中科院分区：
文献类型：
--
作者：
Camprodon, Joan Albert;Martinez-Raga, Jose;Pascual-Leone, Alvaro
背景：可卡因依赖是一个影响美国200万人的公共卫生问题。渴望是一个预测随后的可卡因使用，并涉及到网络中的大脑活动的变化，涉及前额叶cortex.Methods：我们调查了一个会话的高频率重复经颅磁刺激（rTMS），以减少可卡因成瘾的主题渴望的疗效。6例患者接受了两次10 Hz rTMS在左或右背外侧前额叶皮层（DLPFC）。在rTMS治疗前、治疗后即刻和治疗后4小时，我们用视觉模拟量表测量了渴求。但不离开，DLPFC刺激随时间显著降低了渴望（F（2，10）= 11.07，p=0.0029）。较基线降低19%（13.4-24.6%），4小时后消失。时间与刺激部位对渴求的相互作用也是显著的（F（2，25）= 6.13，p = 0.0068）。结论：10 Hz rTMS的一个会话超过右侧，但不是左侧，DLPFC短暂地减少可卡因依赖个体的渴求。这些结果突出了非侵入性神经调节作为可卡因成瘾治疗工具的潜力。(c)2006爱思唯尔爱尔兰有限公司保留所有权利。
Background: Cocaine dependence is a public health problem affecting 2 million individuals in USA. Craving is a predictor of subsequent cocaine use and is related to changes in brain activity in networks involving the prefrontal cortex.Methods: We investigated the efficacy of one session of high frequency repetitive transcranial magnetic stimulation (rTMS) to reduce craving in cocaine addicted subjects. Six patients underwent two sessions of 10 Hz rTMS over left or right dorsolateral prefrontal cortex (DLPFC). Before, immediately after and 4 h after rTMS we measured craving using visual analogue scales.Results: Right. but not left, DLPFC stimulation significantly reduced craving over time (F(2,10)= 11.07, p=0.0029). The reduction was 19% (13.4-24.6%) from baseline and disappeared after 4 h. The interaction of time by site of stimulation for craving was also significant (F(2,25) = 6.13, p = 0.0068).Conclusion: One session of 10 Hz rTMS over right, but not left, DLPFC transiently reduces craving in cocaine dependent individuals. These results highlight the potential of non-invasive neuromodulation as a therapeutic tool for cocaine addiction. (c) 2006 Elsevier Ireland Ltd. All rights reserved.