Arterial baroreflex - A novel target for preventing stroke in rat hypertension
Arterial baroreflex - A novel target for preventing stroke in rat hypertension
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DOI：
10.1161/strokeaha.106.480061
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发表时间：
2007-06-01
期刊：
影响因子：
8.3
通讯作者：
Su, Ding-Feng
中科院分区：
文献类型：
--
作者：
Liu, Ai-Jun;Ma, Xiu-Juan;Su, Ding-Feng
背景和目的-动脉压力感受性反射是调节心血管活动的最重要机制之一。动脉压力感受性反射功能可表示为压力感受性反射敏感性(BRS)。本研究旨在验证两个假设：(1)BRS是高血压患者发生卒中的新的独立预测因子，(2)BRS的恢复可以预防高血压患者的卒中。方法-首先，选择82只28~30周的易卒中自发性高血压大鼠(SHR-SP)。测量血压和BRS，观察存活时间。第二组为8月龄自发性高血压大鼠12只。分别测定灌胃给药酮安色林(0.3 mg/kg和3.0 mg/kg)前后的血压和BRS。给5月龄SHR-SP灌胃0.3 mg/(kg·d)和3.0 mg/(kg·d)的酮色林，连续12周。治疗结束后，测定血压和BRS，并评估终末器官损害。结果高BRS组大鼠卒中时间较低BRS组明显延迟(至50%死亡时间是低BRS组的1.47倍；P<；0.01)。Ketanserin 3.0 mg/kg/d可降低血压，增加BRS，而0.3 mg/kg/d仅使BRS增加。通过两种剂量的治疗，致命的中风发生率显著降低(P<；0.0001与对照组相比)。结论--本研究提供了证据，证明BRS是高血压患者中风的独立预测因子。BRS的恢复可能是预防中风的一种新策略。
Background and Purpose - Arterial baroreflex is one of the most important mechanisms in the regulation of cardiovascular activities. Arterial baroreflex function can be expressed as baroreflex sensitivity ( BRS). The present study was designed to test 2 hypotheses: ( 1) BRS is a new independent predictor for the incidence of stroke in hypertension, and ( 2) restoration of BRS can prevent stroke in hypertension.Methods - First, 82 stroke- prone spontaneously hypertensive rats ( SHR- SP) aged 28 to 30 weeks were used. After measuring blood pressure and BRS, the survival time was observed. Second, 12 SHR- SP aged 8 months were used. Blood pressure and BRS were determined separately before and after intragastric administration of ketanserin ( 0.3 and 3.0 mg/ kg). Third, SHR- SP aged 5 months were treated with ketanserin for 12 weeks ( 0.3 mg and 3.0 mg/ kg per day). At the end of the treatment, blood pressure and BRS were determined and the end- organ damage was evaluated. Last, SHR- SP aged 3 months were treated with ketanserin ( 0.3 and 3.0 mg/ kg per day) for life and the survival time was recorded.Results - Stroke was significantly delayed in rats with high BRS than those with low BRS ( time to 50% death was 1.47- fold longer than low BRS group; P < 0.01). Ketanserin of 3.0 mg/ kg per day decreased blood pressure and enhanced BRS, whereas 0.3 mg/ kg per day only enhanced the BRS. Fatal stroke incidences were markedly reduced by treatment with both doses ( P < 0.0001 versus control group).Conclusions - The present study provides evidence that BRS is an independent predictor for stroke in hypertension. Restoration of BRS may be a new strategy for the prevention of stroke.