Genomewide clonal. analysis of lethal mutations in the Drosophila melanogaster eye:: Comparison of the X chromosome and autosomes
Genomewide clonal. analysis of lethal mutations in the Drosophila melanogaster eye:: Comparison of the X chromosome and autosomes
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DOI：
10.1534/genetics.107.077735
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发表时间：
2007-10-01
期刊：
影响因子：
3.3
通讯作者：
Banerjee, Utpal
中科院分区：
文献类型：
--
作者：
Call, Gerald B.;Olson, John M.;Banerjee, Utpal
在加州大学洛杉矶分校（UCLA）的一个有组织的项目中，我们利用一个大型本科生联盟，对果蝇的眼睛进行了功能基因组筛选。除了基于发现的学习的教育价值，这篇文章提出了第一个全面的全基因组分析的必要基因参与眼睛发育。数据揭示了一个令人惊讶的结果，即X染色体上与眼睛发育有关的基本基因的频率几乎是在染色体上发现的两倍。
Using a large consortium of undergraduate students in an organized program at the University of California, Los Angeles (UCLA), we have undertaken a functional genomic screen in the Drosophila eye. In addition to the educational value of discovery-based learning, this article presents the first comprehensive genomewide analysis of essential genes involved in eye development. The data reveal the surprising result that the X chromosome has almost twice the frequency of essential genes involved in eye development as that found on the amosomes.