Adaptation to Climate Across the Arabidopsis thaliana Genome
Adaptation to Climate Across the Arabidopsis thaliana Genome
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DOI：
10.1126/science.1209244
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发表时间：
2011-10-07
期刊：
影响因子：
56.9
通讯作者：
Bergelson, Joy
中科院分区：
文献类型：
--
作者：
Hancock, Angela M.;Brachi, Benjamin;Bergelson, Joy
了解适应当前气候条件的遗传基础和模式对于准确预测对未来环境变化的反应至关重要。我们进行了全基因组扫描，以确定植物拟南芥中的气候适应性遗传位点和途径。氨基酸变化的变体显着丰富的基因座强烈相关的气候，这表明我们的扫描有效地检测适应性等位基因。此外，从我们的研究结果，我们成功地预测了一组地理上不同的A。在共同的环境中一起生长时，我们的研究结果提供了一组候选人解剖气候适应的分子基础，以及对选择性扫描的流行程度的见解，这对预测适应率有影响。
Understanding the genetic bases and modes of adaptation to current climatic conditions is essential to accurately predict responses to future environmental change. We conducted a genome-wide scan to identify climate-adaptive genetic loci and pathways in the plant Arabidopsis thaliana. Amino acid-changing variants were significantly enriched among the loci strongly correlated with climate, suggesting that our scan effectively detects adaptive alleles. Moreover, from our results, we successfully predicted relative fitness among a set of geographically diverse A. thaliana accessions when grown together in a common environment. Our results provide a set of candidates for dissecting the molecular bases of climate adaptations, as well as insights about the prevalence of selective sweeps, which has implications for predicting the rate of adaptation.